INT23491

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Context Info
Confidence 0.65
First Reported 1973
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 7.20
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FSHB) small molecule metabolic process (FSHB) extracellular region (FSHB)
cellular nitrogen compound metabolic process (FSHB) cytoplasm (FSHB)
Anatomy Link Frequency
Pituitary 1
granulosa cells 1
ovary 1
FSHB (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 2 99.88 Very High Very High Very High
Dismenorea 1 98.82 Very High Very High Very High
narcan 10 97.68 Very High Very High Very High
headache 3 97.12 Very High Very High Very High
Enkephalin 1 90.68 High High
Opioid 3 88.64 High High
corticosteroid 1 77.32 Quite High
opiate 3 75.84 Quite High
agonist 4 75.00 Quite High
Pain 12 72.40 Quite High
Disease Link Frequency Relevance Heat
Cancer 93 99.90 Very High Very High Very High
Polycystic Ovary Syndrome 60 99.40 Very High Very High Very High
Reprotox - General 1 2 98.82 Very High Very High Very High
Vomiting 1 97.64 Very High Very High Very High
Headache 3 97.12 Very High Very High Very High
Hyperinsulinism 1 93.64 High High
Confusion 6 91.84 High High
Heart Rate Under Development 24 90.76 High High
Thyroid Disease 66 89.44 High High
Arrhythmias 2 Under Development 54 88.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hormone testing revealed increased serum levels of FSH and decreased serum levels of LH.
Positive_regulation (increased) of FSH
1) Confidence 0.65 Published 2003 Journal Ann. Endocrinol. (Paris) Section Abstract Doc Link 12910066 Disease Relevance 1.13 Pain Relevance 0.27
Premenstrual syndrome, short luteal phase, and polycystic ovarian dystrophy are increasing degrees of low LH, limited FSH (invariant in polycystic ovary), resulting in low estradiol and hydroxyprogesterone.
Positive_regulation (increasing) of FSH in ovary associated with dismenorea and polycystic ovary syndrome
2) Confidence 0.64 Published 1973 Journal Nouv Presse Med Section Abstract Doc Link 4685762 Disease Relevance 0.20 Pain Relevance 0.10
In total, 24.9% of patients with prior experience of daily injections with FSH had previously used the reusable follitropin beta pen.


Positive_regulation (used) of follitropin beta
3) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0.08 Pain Relevance 0
Patients who had used both pen devices scored many attributes of the prefilled follitropin alfa pen more favourably than those of the reusable follitropin beta pen, including the device storage, device use and dose preparation [15].
Positive_regulation (attributes) of follitropin beta
4) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0.09 Pain Relevance 0.05
In total, 24.9% of patients with prior experience of daily injections with FSH had previously used the reusable follitropin beta pen.


Positive_regulation (reusable) of follitropin beta
5) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0.08 Pain Relevance 0
This was significantly more than the proportion of participants who chose the reusable follitropin beta pen as their preferred device (24.5%; p < 0.0001).
Positive_regulation (reusable) of follitropin beta
6) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0.07 Pain Relevance 0
A greater proportion of patients in the group using the prefilled follitropin alfa pen found the pen very easy to handle, and quicker to learn to use and prepare for injection than those using the reusable follitropin beta pen.
Positive_regulation (reusable) of follitropin beta
7) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0 Pain Relevance 0.13
Patients who had used both pen devices scored many attributes of the prefilled follitropin alfa pen more favourably than those of the reusable follitropin beta pen, including the device storage, device use and dose preparation [15].
Positive_regulation (reusable) of follitropin beta
8) Confidence 0.29 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2949697 Disease Relevance 0.09 Pain Relevance 0.05
Pituitary function tests showed testosterone levels were elevated at 43.10 (Normal range: 10.00 – 31.00 nmol/L) along with elevated FSH, 18.1 (Normal range: 18.1 U/L) and elevated LH at 12.4 (1.0–8.0 U/L).
Positive_regulation (elevated) of FSH in Pituitary
9) Confidence 0.23 Published 2008 Journal J Med Case Reports Section Body Doc Link PMC2270282 Disease Relevance 0.65 Pain Relevance 0
There was a tendency towards a concomitant increment in FSH levels, which reached statistical significance variably from 60 to 105 min post-naloxone.
Positive_regulation (increment) of FSH associated with narcan
10) Confidence 0.20 Published 1981 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6790206 Disease Relevance 0.15 Pain Relevance 0.58
Testosterone was elevated at 43.10 (Normal range: 10.00 – 31.00 nmol/L) with an elevated FSH, 18.1 (1.0–7.0 U/L) and elevated LH, 12.4 (1.0–8.0 U/L).
Positive_regulation (elevated) of FSH
11) Confidence 0.16 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2270282 Disease Relevance 1.30 Pain Relevance 0
Testosterone was elevated at 43.10 (Normal range: 10.00 – 31.00 nmol/L) with an elevated FSH, 18.1 (1.0–7.0 U/L) and elevated LH, 12.4 (1.0–8.0 U/L).
Positive_regulation (elevated) of FSH
12) Confidence 0.16 Published 2008 Journal J Med Case Reports Section Abstract Doc Link PMC2270282 Disease Relevance 1.29 Pain Relevance 0
Furthermore, it is unclear if the PCOS-related hyperinsulinemic state could induce the development of antral follicles by increasing the sensitivity of granulosa cells to FSH determining an higher number of follicles and a major ovarian volume [15-17].
Positive_regulation (increasing) of FSH in granulosa cells associated with polycystic ovary syndrome
13) Confidence 0.13 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2912910 Disease Relevance 0.97 Pain Relevance 0
By IHC, about 40% of the tumors are positive for FSH?
Positive_regulation (positive) of FSH associated with cancer
14) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2522328 Disease Relevance 1.10 Pain Relevance 0.08
In the hpg mice receiving both estradiol and 1 IU rhFSH there was also a proportionate increase in FSH compare to the hpg mice receiving estradiol only.


Positive_regulation (increase) of FSH
15) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
In the hpg mice receiving estradiol only, there was a significant increase (p < 0.05) in circulating FSH (Fig. 3E).
Positive_regulation (increase) of FSH
16) Confidence 0.08 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
Serum FSH concentrations were measured using both a commercially available human FSH ELISA kit (IDS Ltd UK) to determine the levels of recombinant hFSH circulating, and a rat FSH immunoradiometric kit (IDS Ltd UK) in order to estimate the total circulating FSH concentrations (i.e. endogenous and exogenous).
Positive_regulation (circulating) of FSH
17) Confidence 0.06 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0
It was found, however, that [D-pGlu1, D-Phe2, D-Trp3,6]-GnRH, a specific GnRH receptor antagonist, did reduce hBE-induced LH and FSH release (p less than 0.05).
Positive_regulation (reduce) of FSH associated with antagonist
18) Confidence 0.06 Published 1985 Journal Peptides Section Abstract Doc Link 2417204 Disease Relevance 0 Pain Relevance 0.53
Although this stimulatory effect of estradiol may seem like a paradoxical response in a male mammal, it was demonstrably the case that circulating FSH levels were increased in this and previous studies in the hpg mouse.
Positive_regulation (increased) of FSH
19) Confidence 0.05 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2254628 Disease Relevance 0 Pain Relevance 0

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