INT234912

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Anatomy Link Frequency
cleavage 2
skin 1
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 6 42.20 Quite Low
Kinase C 39 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Embryonic Lethality 9 97.02 Very High Very High Very High
Adhesions 153 96.80 Very High Very High Very High
Autoimmune Disease 12 95.24 Very High Very High Very High
Bullous Skin Disease 912 94.48 High High
Disease 54 91.12 High High
Acantholysis 195 91.04 High High
Carcinoma 3 78.80 Quite High
Skin Cancer 3 77.28 Quite High
Breast Cancer 3 72.56 Quite High
Cancer 9 62.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteolytic cleavage of desmosomal cadherins
Protein_catabolism (cleavage) of desmosomal in cleavage
1) Confidence 0.05 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.07 Pain Relevance 0
Inactivation of desmosomal function may be reduced by completely different mechanisms including genetic defects of desmosomal components, cleavage of desmosomal cadherins by bacterial toxins and binding of autoantibodies to desmogleins 1, the latter of which is the cause of the autoimmune disease pemphigus.
Protein_catabolism (cleavage) of desmosomal in cleavage associated with autoimmune disease and bullous skin disease
2) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.88 Pain Relevance 0
The importance of this linker function can be concluded from studies in which inactivation of plakoglobin led to embryonic lethality due to mechanical fragility of the myocardium and, when mice are viable, to subcorneal skin blistering indicating that plakoglobin is essential for desmosomal stability (TableĀ 1) (Bierkamp et al. 1996; Ruiz et al. 1996).
Protein_catabolism (stability) of desmosomal in skin associated with embryonic lethality
3) Confidence 0.03 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0

General Comments

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