INT234914

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.47
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
cardiomyocytes 2
Pkp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Heart Defects 8 99.30 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 6 99.16 Very High Very High Very High
Alopecia 4 94.72 High High
Arrhythmia Under Development 2 94.56 High High
Adhesions 102 90.36 High High
Death 2 90.16 High High
Disease 36 66.84 Quite High
Cancer 6 65.24 Quite High
Embryonic Lethality 6 63.04 Quite High
Cv General 4 Under Development 2 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, all defects of desmosomal components causing heart defects such as desmoplakin, plakoglobin, plakophilin 2, Dsg 2 and Dsc 2 lead to the phenotype of arrhythmogenic right ventricular cardiomyopathy (ARVC) which is clinically characterized by right bundle block and arrhythmia and histologically by fibrofatty replacement of cardiomyocytes, possibly due to impaired cell adhesion caused by loss and alterations of desmosomes (Asimaki et al. 2007; Gerull et al. 2004; McKoy et al. 2000; Pilichou et al. 2006; Rampazzo et al. 2002; Syrris et al. 2006; Heuser et al. 2006).
Localization (lead) of plakophilin 2 in cardiomyocytes associated with arrhythmia under development, heart defects, adhesions and arrhythmogenic right ventricular dysplasia
1) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.29 Pain Relevance 0
Under these conditions, cytokeratin filaments were retracted from cell borders and desmoplakin was localized in the cytoplasm rather than at desmosomes in cardiomyocytes, demonstrating the relevance of plakophilin 2 to desmosplakin recruitment.
Localization (localized) of plakophilin 2 in cardiomyocytes
2) Confidence 0.06 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.18 Pain Relevance 0

General Comments

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