INT234915

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.70
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Anatomy Link Frequency
keratinocytes 4
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 66.60 Quite High
antagonist 3 44.36 Quite Low
Kinase C 39 5.00 Very Low Very Low Very Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 57 100.00 Very High Very High Very High
Bullous Skin Disease 912 99.90 Very High Very High Very High
Acantholysis 195 98.88 Very High Very High Very High
Embryonic Lethality 9 75.08 Quite High
Repression 6 50.48 Quite High
Adhesions 153 21.60 Low Low
Cancer 9 9.60 Low Low
Disease 54 5.00 Very Low Very Low Very Low
Blister 36 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As outlined above, PV-IgG-induced plakoglobin depletion resulted in c-Myc overexpression in cultured keratinocytes (Muller et al. 2008a; Williamson et al. 2006).
Positive_regulation (induced) of Gene_expression (depletion) of plakoglobin in keratinocytes associated with bullous skin disease
1) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.09 Pain Relevance 0.06
Because plakoglobin like ?
Positive_regulation (Because) of Spec (like) Gene_expression (like) of plakoglobin
2) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.13 Pain Relevance 0
These mechanisms may, amongst others, involve expression of genes different from c-Myc, which is suggested by the fact that plakoglobin deficiency resulted in protection of keratinocytes from apoptosis, possibly via overexpression of the anti-apoptotic molecule Bcl-XL (Dusek et al. 2007a).
Positive_regulation (overexpression) of Gene_expression (overexpression) of plakoglobin in keratinocytes associated with apoptosis
3) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.49 Pain Relevance 0

General Comments

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