INT234917

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 3.16
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Anatomy Link Frequency
epidermis 2
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 26 85.96 High High
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 608 99.44 Very High Very High Very High
Acantholysis 130 98.68 Very High Very High Very High
Blister 24 65.16 Quite High
Stress 8 31.76 Quite Low
Adhesions 102 5.00 Very Low Very Low Very Low
Apoptosis 38 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 12 5.00 Very Low Very Low Very Low
Skin Diseases 10 5.00 Very Low Very Low Very Low
Heart Defects 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In line with these findings, forced expression of Dsg 3 in the superficial epidermis abolished the ability of PF-IgG to induce acantholysis in mice (Wu et al. 2000).
Negative_regulation (abolished) of Gene_expression (expression) of Dsg 3 in epidermis associated with acantholysis and bullous skin disease
1) Confidence 0.31 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.89 Pain Relevance 0
For instance, direct inhibition of Dsg 3 transinteraction was found in PV but not in PF under conditions where antibodies caused acantholysis (Heupel et al. 2007).
Negative_regulation (inhibition) of Gene_expression (transinteraction) of Dsg 3 associated with acantholysis and bullous skin disease
2) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 2.26 Pain Relevance 0.09

General Comments

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