INT234918

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Context Info
Confidence 0.15
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell morphogenesis (Jup) cytoplasm (Jup) cytosol (Jup)
structural molecule activity (Jup) cell adhesion (Jup) nucleus (Jup)
Jup (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 608 99.70 Very High Very High Very High
Adhesions 102 98.60 Very High Very High Very High
Acantholysis 130 92.72 High High
Repression 4 10.24 Low Low
Apoptosis 38 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Blister 24 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 12 5.00 Very Low Very Low Very Low
Skin Diseases 10 5.00 Very Low Very Low Very Low
Heart Defects 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data indicate that plakoglobin is required to integrate the effects from extracellular cues and from different signalling pathways in order to allow coordinated modulation of desmosomal adhesion.
Positive_regulation (required) of plakoglobin associated with adhesions
1) Confidence 0.15 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.55 Pain Relevance 0
Besides its involvement in PV pathogenesis, plakoglobin is important for several aspects of desmosomal adhesion.
Positive_regulation (important) of plakoglobin associated with bullous skin disease and adhesions
2) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.53 Pain Relevance 0

General Comments

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