INT234922

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 6.01
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Dsp) structural molecule activity (Dsp) cytoskeleton (Dsp)
protein binding, bridging (Dsp) cytoplasm (Dsp)
Anatomy Link Frequency
keratinocyte 2
cleavage 1
skin 1
Dsp (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 78 82.88 Quite High
addiction 12 43.56 Quite Low
metalloproteinase 36 5.00 Very Low Very Low Very Low
agonist 30 5.00 Very Low Very Low Very Low
corticosteroid 12 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 1824 99.52 Very High Very High Very High
Acantholysis 390 99.24 Very High Very High Very High
Adhesions 306 94.64 High High
Autoimmune Disease 24 93.84 High High
Disease 108 92.48 High High
Stress 24 90.00 High High
Carcinoma 6 76.00 Quite High
Skin Cancer 6 74.48 Quite High
Breast Cancer 6 69.76 Quite High
Repression 12 61.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
With respect to pemphigus, it has been shown that plakoglobin is critical for PV pathogenesis because keratinocytes from plakoglobin-deficient mice were resistant to PV-IgG-induced keratinocyte dissociation, cytokeratin retraction and disruption of the desmosomal plaque (Caldelari et al. 2001; de Bruin et al. 2007).
Negative_regulation (disruption) of desmosomal in keratinocytes associated with bullous skin disease
1) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.73 Pain Relevance 0
The major goal for the future is to elucidate the primary signalling pathways responsible for the diverse effects of pemphigus IgG such as inhibition of desmoglein binding, depletion of desmosomal components, loss of desmosomes, reorganization of the cytoskeleton and finally the induction of acantholysis.
Negative_regulation (depletion) of desmosomal associated with acantholysis and bullous skin disease
2) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.36 Pain Relevance 0.04
It is well established that pemphigus autoantibodies lead to depletion of desmosomal components from desmosomes as well as from the cell surface.
Negative_regulation (depletion) of desmosomal associated with bullous skin disease
3) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.64 Pain Relevance 0
Inactivation of desmosomal function may be reduced by completely different mechanisms including genetic defects of desmosomal components, cleavage of desmosomal cadherins by bacterial toxins and binding of autoantibodies to desmogleins 1, the latter of which is the cause of the autoimmune disease pemphigus.
Negative_regulation (defects) of desmosomal in cleavage associated with autoimmune disease and bullous skin disease
4) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.87 Pain Relevance 0
For instance, acantholysis may foster skin blistering by derangement of the epidermal Ca2+ gradient, which in turn would result in loss of desmosomal cadherin binding, especially when the tight junctions of the granular layer are affected.



Negative_regulation (loss) of desmosomal cadherin in skin associated with acantholysis
5) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.49 Pain Relevance 0.04
However, even if depletion of desmosomal components occured secondary to keratinocyte dissociation, it likely would further aggravate the loss of keratinocyte cohesion.
Negative_regulation (depletion) of desmosomal in keratinocyte
6) Confidence 0.02 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.92 Pain Relevance 0

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