INT234923

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Context Info
Confidence 0.34
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.80
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsc2) plasma membrane (Dsc2)
Anatomy Link Frequency
myocardium 1
epidermis 1
oral mucosa 1
Dsc2 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 2 6.72 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 79 98.48 Very High Very High Very High
Heart Defects 4 98.44 Very High Very High Very High
Disease 52 85.92 High High
Acantholysis 81 85.56 High High
Cancer 3 84.32 Quite High
Breast Cancer 1 79.80 Quite High
Skin Cancer 1 77.68 Quite High
Carcinoma 1 76.40 Quite High
Alopecia 24 75.28 Quite High
Bullous Skin Disease 382 71.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The combination of DSC1 and DSC2 is thus likely to maintain cell-cell adhesion in oral mucosa in the absence of DSC3 (Figure 1, and data not shown).
DSC2 Binding (combination) of in oral mucosa associated with adhesions
1) Confidence 0.34 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.25 Pain Relevance 0
Nevertheless, in humans and cows, it is known that Dsc2 is only weakly expressed or even absent in most of the interfollicular epidermis, with the notable exception of the palms and soles (see [9]).
Dsc2 Binding (absent) of in epidermis
2) Confidence 0.34 Published 2010 Journal Dermatology Research and Practice Section Body Doc Link PMC2879910 Disease Relevance 0.36 Pain Relevance 0
In contrast, genetic alterations of Dsg 2, Dsc 2 and plakophilin 2 selectively lead to heart defects because these are the only isoforms of their protein families in the myocardium.
Dsc 2 Binding (alterations) of in myocardium associated with heart defects
3) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.20 Pain Relevance 0

General Comments

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