INT234925

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.52
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hspb2) response to stress (Hspb2) cytoplasm (Hspb2)
Anatomy Link Frequency
keratinocytes 4
filaments 2
Hspb2 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 39 75.48 Quite High
metalloproteinase 18 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 912 99.74 Very High Very High Very High
Shock 6 98.04 Very High Very High Very High
Mucocutaneous Lymph Node Syndrome 3 97.84 Very High Very High Very High
Blister 36 91.20 High High
Acantholysis 195 81.60 Quite High
Adhesions 153 78.80 Quite High
Apoptosis 57 5.00 Very Low Very Low Very Low
Disease 54 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 18 5.00 Very Low Very Low Very Low
Skin Diseases 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because p38MAPK-mediated phosphorylation of HSP27 or HSP 25 promoted actin assembly and stabilized F-actin against depolymerization in response to cytochalasin D or heat shock (Benndorf et al. 1994; Geum et al. 2002; Guay et al. 1997), one would expect that PV-IgG-induced HSP27 phosphorylation also would stabilize actin filaments.
Positive_regulation (stabilize) of Phosphorylation (phosphorylation) of HSP27 in filaments associated with shock and bullous skin disease
1) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.66 Pain Relevance 0
In cultured human keratinocytes, phosphorylation of p38MAPK and HSP27 occured after 30 min of exposure to PV-IgG (Berkowitz et al. 2005; Kawasaki et al. 2006).
Positive_regulation (occured) of Phosphorylation (phosphorylation) of HSP27 in keratinocytes associated with mucocutaneous lymph node syndrome and bullous skin disease
2) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.43 Pain Relevance 0.10
In cultured human keratinocytes, phosphorylation of p38MAPK and HSP27 occured after 30 min of exposure to PV-IgG (Berkowitz et al. 2005; Kawasaki et al. 2006).
Positive_regulation (after) of Phosphorylation (phosphorylation) of HSP27 in keratinocytes associated with mucocutaneous lymph node syndrome and bullous skin disease
3) Confidence 0.10 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.43 Pain Relevance 0.10

General Comments

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