INT234928

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.72
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 30
Disease Relevance 17.04
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Hspb1) cytoskeleton (Hspb1) nucleus (Hspb1)
intracellular (Hspb1) response to stress (Hspb1) cytoplasm (Hspb1)
Anatomy Link Frequency
podocytes 7
cleavage 5
monocyte 1
filaments 1
Hspb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 3 95.80 Very High Very High Very High
cytokine 15 95.00 High High
rheumatoid arthritis 65 88.96 High High
Inflammation 127 83.84 Quite High
methotrexate 4 73.84 Quite High
Arthritis 64 70.76 Quite High
anesthesia 28 56.56 Quite High
COX-2 inhibitor 28 24.16 Low Low
Bioavailability 56 10.04 Low Low
Kinase C 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 87 100.00 Very High Very High Very High
Apoptosis 764 99.70 Very High Very High Very High
Diabetes Mellitus 1456 99.52 Very High Very High Very High
Stress 284 98.24 Very High Very High Very High
Death 116 97.28 Very High Very High Very High
Injury 28 97.28 Very High Very High Very High
Heat Stress Disorders 28 97.20 Very High Very High Very High
INFLAMMATION 102 95.80 Very High Very High Very High
Bullous Skin Disease 304 92.04 High High
Renal Disease 1092 91.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
Phosphorylation (phosphorylation) of HSP25 in podocytes
1) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.25 Pain Relevance 0
HSP25, the rodent homolog of human HSP27, is phosphorylated by upstream p38 mitogen-activated protein kinase (p38MAPK).
Phosphorylation (phosphorylated) of HSP25
2) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.62 Pain Relevance 0
As anticipated, the biphosphorylated HSP25/total HSP25 ratio also significantly increased when Cur30 ?
Phosphorylation (biphosphorylated) of HSP25
3) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
Incubation of podocytes in high glucose medium for as briefly as 4 hours with a p38MAPK inhibitor attenuated downstream HSP25 phosphorylation, inducing F- to G-actin cleavage, and cytoskeletal disruption.
Phosphorylation (phosphorylation) of HSP25 in cleavage
4) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.25 Pain Relevance 0
Phosphorylated HSP25 plays a key role in the regulation of actin cytoskeletal dynamics [11-17].
Phosphorylation (Phosphorylated) of HSP25
5) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.58 Pain Relevance 0
We have previously shown in podocytes cultured under normal or high glucose conditions, and in renal cortical tissue from diabetic and control rats, that phosphorylated HSP25 appears as an acute adaptation to glycemic stress.
Phosphorylation (phosphorylated) of HSP25 in podocytes associated with stress and diabetes mellitus
6) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.09 Pain Relevance 0
The ability of Cur to stimulate phosphorylation of p38MAPK and HSP25 in both normal glucose (NG, 5.5 mM) and high glucose (HG, 30 mM) media was assessed.
Phosphorylation (phosphorylation) of HSP25
7) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.05 Pain Relevance 0.05
Isoelectric focusing (IEF) was performed to measure concentrations of phosphorylated HSP25 as described previously [2,3].
Phosphorylation (phosphorylated) of HSP25
8) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
Since phosphorylated p38MAPK is one of the major regulators of the phosphorylation of downstream HSP25, activation of the p38MAPK-HSP25 pathway may explain both the tendency towards maintenance of the actin cytoskeleton and the attenuation of apoptosis in this in vitro model.
Phosphorylation (phosphorylation) of HSP25 associated with apoptosis
9) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.97 Pain Relevance 0
In cultured podocytes, curcumin induced the phosphorylation of p38MAPK and downstream HSP25, inhibited COX-2 and the activation of caspase-3, and demonstrated a tendency to attenuate F-actin cleavage to G-actin monomers.
Phosphorylation (phosphorylation) of HSP25 in cleavage
10) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.79 Pain Relevance 0
As anticipated, the biphosphorylated HSP25/total HSP25 ratio also significantly increased when Cur30 ?
Phosphorylation (biphosphorylated) of HSP25
11) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0
Incubation of podocytes in high glucose medium for hours, or incubation with a p38MAPK inhibitor, attenuated downstream HSP25 phosphorylation, inducing F- to G-actin cleavage, and cytoskeletal disruption.
Phosphorylation (phosphorylation) of HSP25 in cleavage
12) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.21 Pain Relevance 0
We previously showed in vitro that short-term incubation of podocytes in medium with a high glucose concentration (up to 4 hours) resulted in phosphorylation of p38MAPK and downstream HSP25, associated with maintenance of the actin cytoskeleton.
Phosphorylation (phosphorylation) of HSP25 in podocytes
13) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.50 Pain Relevance 0
Phosphorylated HSP25 monomers play a role in the maintenance of the actin cytoskeleton during cell stress [11,13,66-69].
Phosphorylation (Phosphorylated) of HSP25 associated with stress
14) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.00 Pain Relevance 0
Through the stabilization of actin, phosphorylated HSP25 may attenuate apoptosis.
Phosphorylation (phosphorylated) of HSP25 associated with apoptosis
15) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.86 Pain Relevance 0
Cur stimulates phosphorylation of p38MAPK and HSP25 in cultured podocytes
Phosphorylation (phosphorylation) of HSP25 in podocytes
16) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.06 Pain Relevance 0.06
The anti-apoptotic activities of phosphorylated HSP25/27 in cells exposed to TNF?
Phosphorylation (phosphorylated) of HSP25 associated with apoptosis
17) Confidence 0.72 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.96 Pain Relevance 0
These data underscore the significant relationship between phosphorylated and non-phosphorylated HSP25/27 with cytoskeletal maintenance and cytoprotection from apoptotic death.
Phosphorylation (phosphorylated) of HSP25 associated with apoptosis and death
18) Confidence 0.71 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 1.38 Pain Relevance 0
The effects of Cur on the phosphorylated p38 mitogen-activated protein kinase (pp38MAPK) - phosphorylated HSP25/27 (pHSP25/27) signaling pathway in the presence and absence of glycemic stress were assessed with the following treatment groups: 1) 5.5 mM glucose for 60-70 min (normal glucose, NG); 2) 5.5 mM glucose with 30 uM Cur for 60-70 min (NG+Cur); 3) 5.5 mM glucose for 60 min immediately replaced by 30 mM glucose for 10 min (high glucose, HG); 4) 5.5 mM glucose with 30 ?
Phosphorylation (phosphorylated) of HSP25 associated with stress
19) Confidence 0.71 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0.19 Pain Relevance 0
Our published work showed that incubating Pods in HG for up to 24 hrs stimulated the phosphorylation of p38MAPK and HSP25 while maintaining the actin cytoskeleton [18].
Phosphorylation (phosphorylation) of HSP25
20) Confidence 0.71 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC2999583 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox