INT234929

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Context Info
Confidence 0.31
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 3.12
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 39 79.52 Quite High
metalloproteinase 18 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 912 97.88 Very High Very High Very High
Acantholysis 195 95.44 Very High Very High Very High
Adhesions 153 26.52 Quite Low
Blister 36 21.60 Low Low
Disease 54 17.92 Low Low
Apoptosis 57 14.68 Low Low
Vohwinkel Syndrome 18 5.00 Very Low Very Low Very Low
Skin Diseases 15 5.00 Very Low Very Low Very Low
Heart Defects 12 5.00 Very Low Very Low Very Low
Skin Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, other mechanisms such as direct inhibition of Dsg 3 binding and Dsg 3 depletion from desmosomes as well as other signalling events seem to contribute to PV pathogenesis, whereas their role for acantholysis in PF is unclear.
Negative_regulation (inhibition) of Negative_regulation (depletion) of Dsg 3 associated with acantholysis and bullous skin disease
1) Confidence 0.31 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.47 Pain Relevance 0.08
In addition, other mechanisms such as direct inhibition of Dsg 3 binding and Dsg 3 depletion from desmosomes as well as other signalling events seem to contribute to PV pathogenesis, whereas their role for acantholysis in PF is unclear.
Negative_regulation (inhibition) of Negative_regulation (depletion) of Dsg 3 associated with acantholysis and bullous skin disease
2) Confidence 0.22 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.47 Pain Relevance 0.08
In contrast, in confluent HaCaT monolayers, a reduction of Dsg 3 half-life but no depletion of total cellular Dsg 3 was detected (Cirillo et al. 2006; Waschke et al. 2006).
Negative_regulation (reduction) of Neg (no) Negative_regulation (depletion) of Dsg 3
3) Confidence 0.19 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.17 Pain Relevance 0

General Comments

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