INT234936

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CCND2) nucleolus (CCND2) nucleus (CCND2)
cell division (CCND2) cytoplasm (CCND2)
Anatomy Link Frequency
keratinocytes 1
CCND2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 51 97.18 Very High Very High Very High
Bullous Skin Disease 304 95.28 Very High Very High Very High
Acantholysis 65 74.88 Quite High
Apoptosis 19 45.44 Quite Low
Disease 18 5.00 Very Low Very Low Very Low
Blister 12 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 6 5.00 Very Low Very Low Very Low
Skin Diseases 5 5.00 Very Low Very Low Very Low
Heart Defects 4 5.00 Very Low Very Low Very Low
Skin Infection 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown by DNA microarray that PV-IgG within 8 h down-regulated transcription of 198 genes including genes encoding for adhesion molecules including Dsg 3 and desmoplakin, cytoskeletal proteins such as different cytokeratins as well as molecules involved in cell cycle regulation such as p53 and cyclin D2 in cultured keratinocytes and that expression of some of these genes was antagonistically regulated by methylprednisolone (Nguyen et al. 2004a).
Regulation (regulation) of cyclin D2 in keratinocytes associated with bullous skin disease and adhesions
1) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.15 Pain Relevance 0

General Comments

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