INT234943

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.81
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG1) plasma membrane (DSG1)
DSG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dentinogenesis Imperfecta 86 100.00 Very High Very High Very High
Acantholysis 65 99.12 Very High Very High Very High
Sensorineural Hearing Loss 2 95.60 Very High Very High Very High
Osteogenesis Imperfecta 15 89.32 High High
Bullous Skin Disease 304 88.24 High High
Hypertrophy 1 74.32 Quite High
Cleidocranial Dysplasia 57 71.52 Quite High
Syndrome 12 53.40 Quite High
Congenital Anomalies 1 19.04 Low Low
Adhesions 52 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is a form of DGI found in a tri-racial population from Maryland and Washington DC known as the Brandywine isolate.
Phosphorylation (form) of DGI associated with dentinogenesis imperfecta
1) Confidence 0.48 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.29 Pain Relevance 0
However, phosphorylation of Dsg 3 was observed in some studies but not in others, which might be due to different cell culture models indicating that Dsg phosphorylation is not necessary for acantholysis (Chernyavsky et al. 2007b; Nguyen et al. 2004a).
Phosphorylation (phosphorylation) of Dsg associated with acantholysis
2) Confidence 0.41 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.53 Pain Relevance 0

General Comments

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