INT234949

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CTNND1) cell adhesion (CTNND1) plasma membrane (CTNND1)
nucleus (CTNND1) cytoplasm (CTNND1)
CTNND1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 10 95.00 High High
antagonist 2 83.00 Quite High
metalloproteinase 12 49.32 Quite Low
Kinase C 26 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 608 99.12 Very High Very High Very High
Acantholysis 130 97.00 Very High Very High Very High
Adhesions 102 74.88 Quite High
Apoptosis 38 70.72 Quite High
Disease 36 5.00 Very Low Very Low Very Low
Blister 24 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 12 5.00 Very Low Very Low Very Low
Skin Diseases 10 5.00 Very Low Very Low Very Low
Heart Defects 8 5.00 Very Low Very Low Very Low
Skin Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-catenin and Src-mediated tyrosine phosphorylation of p120catenin by activation of the specific protein phosphatases (Chernyavsky et al. 2007b).
Phosphorylation (phosphorylation) of p120catenin
1) Confidence 0.61 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.81 Pain Relevance 0.25
Because p120catenin is involved in stabilization of classical cadherins such as E-cadherin on the cell surface as well as in cadherin-dependent regulation of Rho A and Rac 1 activity (Alema and Salvatore 2007; Kowalczyk and Reynolds 2004), Src-mediated phosphorylation of p120catenin may be important for PV pathogenesis.


Phosphorylation (phosphorylation) of p120catenin associated with bullous skin disease
2) Confidence 0.61 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.08 Pain Relevance 0.03

General Comments

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