INT234956

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Context Info
Confidence 0.14
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PKP1) cell adhesion (PKP1) nucleolus (PKP1)
plasma membrane (PKP1) nucleus (PKP1) signal transducer activity (PKP1)
Anatomy Link Frequency
lateral 1
plaque 1
PKP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 26 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 102 78.80 Quite High
Heart Defects 8 59.20 Quite High
Death 2 58.36 Quite High
Cancer 6 16.60 Low Low
Apoptosis 38 6.08 Low Low
Bullous Skin Disease 608 5.00 Very Low Very Low Very Low
Acantholysis 130 5.00 Very Low Very Low Very Low
Disease 36 5.00 Very Low Very Low Very Low
Blister 24 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to their localization within the desmosomal plaque, plakophilin 1 and 2 are also present inside nucleus and plakophilin 2 has been found to be part of the polymerase III complex which is responsible for generation of tRNA and rRNA (Mertens et al. 2001).
Localization (localization) of plakophilin 1 in plaque
1) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.08 Pain Relevance 0
On the other hand, because plakophilin 1 is located in the dense inner desmosomal plaque whereas cytokeratin filaments only loop into the outer plaque, it is believed that plakophilin 1 enhances desmoplakin lateral interactions but does not directly associate with cytokeratin filaments in vivo (Hatzfeld 2007; North et al. 1999).
Localization (located) of plakophilin 1 in lateral
2) Confidence 0.14 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.12 Pain Relevance 0

General Comments

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