INT234962

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 5.41
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG1) plasma membrane (DSG1)
Anatomy Link Frequency
dentine 2
skin 2
DSG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 15 91.76 High High
Kinase C 26 66.88 Quite High
metalloproteinase 12 5.00 Very Low Very Low Very Low
agonist 10 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
corticosteroid 4 5.00 Very Low Very Low Very Low
addiction 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dentinogenesis Imperfecta 172 100.00 Very High Very High Very High
Cleidocranial Dysplasia 114 100.00 Very High Very High Very High
Disease 48 98.64 Very High Very High Very High
Non-genital Cutaneous Warts 2 98.04 Very High Very High Very High
Pancreatic Cancer 38 96.70 Very High Very High Very High
Bullous Skin Disease 608 94.52 High High
Osteogenesis Imperfecta 30 93.44 High High
Pancreatitis 17 91.76 High High
Acantholysis 130 88.48 High High
Adenocarcinoma 14 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The pancreatic cancer samples, however, showed an almost complete loss of cells displaying intense (3+) Dsg1 staining and a marked decrease in cells with 2+ intensity with a concomitant increase in cells with weak (1+) or absent (0+) Dsg1 staining.
Positive_regulation (increase) of Neg (absent) Gene_expression (staining) of Dsg1 associated with pancreatic cancer
1) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2628383 Disease Relevance 0.89 Pain Relevance 0.30
The only mutations causative of DGI and DD, with the exception of DD-I for which the underlying mutation(s) has been elucidated, are found in the dentine sialophosphoprotein gene (DSPP), suggesting that these conditions are indeed allelic (Table 1).
Positive_regulation (causative) of Neg (exception) Gene_expression (found) of DGI in dentine associated with cleidocranial dysplasia and dentinogenesis imperfecta
2) Confidence 0.38 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 1.57 Pain Relevance 0
Dentinogenesis imperfecta (DGI)
Positive_regulation (imperfecta) of Gene_expression (imperfecta) of DGI associated with dentinogenesis imperfecta
3) Confidence 0.38 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2600777 Disease Relevance 2.08 Pain Relevance 0
Similarly, forced suprabasal Dsg 2 and Dsc 3 overexpression resulted in hyperproliferation and formation of papillomas, possibly via altered ?
Positive_regulation (forced) of Gene_expression (overexpression) of Dsg associated with non-genital cutaneous warts
4) Confidence 0.34 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.10 Pain Relevance 0.07
In skin layers where Dsg 1 and Dsg 3 were found, autoantibodies against both desmogleins were required for blistering.
Positive_regulation (required) of Gene_expression (found) of Dsg in skin
5) Confidence 0.25 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.78 Pain Relevance 0

General Comments

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