INT234994

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Dsg3) plasma membrane (Dsg3)
NKS1 (Homo sapiens)
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 1 86.24 High High
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 304 95.36 Very High Very High Very High
Adhesions 51 69.76 Quite High
Hepatitis A Virus Infection 1 52.24 Quite High
Acantholysis 65 5.00 Very Low Very Low Very Low
Apoptosis 19 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Blister 12 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 6 5.00 Very Low Very Low Very Low
Skin Diseases 5 5.00 Very Low Very Low Very Low
Heart Defects 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the recent finding that AK 23 similar to Dsg 3 antibodies from PV patients, which are known to be also primarily directed against the N-terminal part of EC 1 (Sekiguchi et al. 2001), is able to directly interfere with Dsg 3 binding (Heupel et al. 2007), these data demonstrate that interaction of EC 1 is crucial for Dsg 3 binding.
EC 1 Binding (binding) of Dsg 3 associated with bullous skin disease
1) Confidence 0.00 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.50 Pain Relevance 0.04

General Comments

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