INT235008

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Context Info
Confidence 0.11
First Reported 2008
Last Reported 2008
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 4.82
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DSG1, Dsg3) cytosol (DSG1) cell adhesion (Dsg3)
Anatomy Link Frequency
epidermis 1
DSG1 (Homo sapiens)
Dsg3 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 5 7.92 Low Low
corticosteroid 10 6.44 Low Low
Kinase C 65 5.00 Very Low Very Low Very Low
metalloproteinase 30 5.00 Very Low Very Low Very Low
agonist 25 5.00 Very Low Very Low Very Low
addiction 10 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 255 99.52 Very High Very High Very High
Bullous Skin Disease 1520 99.50 Very High Very High Very High
Acantholysis 325 99.12 Very High Very High Very High
Disease 90 91.68 High High
Blister 60 85.16 High High
Epidermolysis Bullosa Acquisita 5 79.84 Quite High
Skin Diseases 25 77.36 Quite High
Autoimmune Disease 20 34.16 Quite Low
Apoptosis 95 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients suffering from mucosal-dominant PV usually have antibodies directed against Dsg 3 but not Dsg 1, whereas mucocutaneous PV is characterized by both Dsg 3 and Dsg 1 autoantibodies (Amagai et al. 1999; Ding et al. 1997; Jamora et al. 2003; Miyagawa et al. 1999).
Dsg Binding (directed) of Dsg 3 associated with bullous skin disease
1) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.46 Pain Relevance 0
Two principal mechanisms have been proposed by which autoantibodies specific for Dsg 1 and Dsg 3 could impair desmosomal adhesion.
Dsg Neg (impair) Binding (impair) of Dsg 3 associated with adhesions
2) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.02 Pain Relevance 0
Heterophilic binding of Dsg 2 to Dsc 1 or Dsc 2 was also found on the molecular level (Chitaev and Troyanovsky 1997; Syed et al. 2002) but no interaction of Dsg 1 with Dsg 3 (Heupel et al. 2007).
Dsg Neg (no) Binding (interaction) of Dsg 3
3) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.36 Pain Relevance 0
In PV, when only Dsg 3 antibodies are present, no epidermal blistering would occur because Dsg 1 is considered to compensate for autoantibody-induced loss of Dsg 3 binding.
Dsg Binding (binding) of Dsg 3 associated with bullous skin disease
4) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.90 Pain Relevance 0
In PV, epidermal involvement would occur only when autoantibodies against both Dsg 1 and Dsg 3 are present because Dsg 1 is found in all epidermal layers and could compensate for loss of Dsg 3 binding when antibodies to Dsg 3 are solely presentFig. 10Immunostaining of Dsg 1 and Dsg 3 in PV lesional epidermis.
Dsg Binding (binding) of Dsg 3 in epidermis associated with bullous skin disease
5) Confidence 0.11 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.08 Pain Relevance 0

General Comments

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