INT235011

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.07
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ctnnd1, RAC1) cell adhesion (Ctnnd1, RAC1) plasma membrane (Ctnnd1, RAC1)
enzyme binding (RAC1) GTPase activity (RAC1) cytoplasm (Ctnnd1)
Anatomy Link Frequency
filaments 1
Ctnnd1 (Mus musculus)
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 13 5.00 Very Low Very Low Very Low
metalloproteinase 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
corticosteroid 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
antagonist 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 51 67.84 Quite High
Heart Defects 4 22.12 Low Low
Death 1 21.28 Low Low
Bullous Skin Disease 304 5.00 Very Low Very Low Very Low
Acantholysis 65 5.00 Very Low Very Low Very Low
Apoptosis 19 5.00 Very Low Very Low Very Low
Disease 18 5.00 Very Low Very Low Very Low
Blister 12 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 6 5.00 Very Low Very Low Very Low
Skin Diseases 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plakophilin 1 associates with actin filaments at cell borders and has been reported to interact with a GTP exchange factor (GEF) for Rho and thereby could regulate activity of Rho GTPases similar to the closely related p120-catenin, which is known to inhibit Rho A and to activate Rac 1 and Cdc42 (Anastasiadis and Reynolds 2001; Hatzfeld 2007).
p120-catenin Positive_regulation (activate) of Rac 1 in filaments
1) Confidence 0.00 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.07 Pain Relevance 0

General Comments

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