INT235016

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Context Info
Confidence 0.04
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (DSG1) plasma membrane (DSG1)
Anatomy Link Frequency
keratinocyte 2
IgG (Mus musculus)
DSG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 39 40.96 Quite Low
metalloproteinase 18 5.00 Very Low Very Low Very Low
agonist 15 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bullous Skin Disease 912 100.00 Very High Very High Very High
Acantholysis 195 87.04 High High
Blister 36 86.88 High High
Adhesions 153 59.84 Quite High
Disease 54 55.72 Quite High
Stress 12 7.00 Low Low
Apoptosis 57 5.00 Very Low Very Low Very Low
Vohwinkel Syndrome 18 5.00 Very Low Very Low Very Low
Skin Diseases 15 5.00 Very Low Very Low Very Low
Heart Defects 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because PF-IgG were shown to induce cellular signalling events but not to directly reduce Dsg 1 binding, it seems that direct inhibition of Dsg transinteraction is not essential to alter Dsg-mediated signalling (Heupel et al. 2007; Waschke et al. 2005).
IgG Negative_regulation (reduce) of Dsg Binding (binding) of associated with bullous skin disease
1) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 1.24 Pain Relevance 0
However, no direct inhibition of Dsg 1 binding by PV-IgG and PF-IgG was detected by AFM.
IgG Negative_regulation (inhibition) of Dsg Binding (binding) of associated with bullous skin disease
2) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.86 Pain Relevance 0
These data indicate that PV-IgG and PF-IgG can reduce binding of Dsg 1 and Dsg 3, at least on the keratinocyte cell surface.
IgG Negative_regulation (reduce) of Dsg Binding (binding) of in keratinocyte associated with bullous skin disease
3) Confidence 0.04 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2413110 Disease Relevance 0.79 Pain Relevance 0

General Comments

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