INT235057

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

chromosome organization (Apc) plasma membrane (Apc) nucleus (Apc)
protein complex assembly (Apc) cytoplasm (Apc)
Anatomy Link Frequency
macrophages 2
Apc (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 93.96 High High
Inflammation 11 40.20 Quite Low
cytokine 4 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Mechanotransduction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 11 100.00 Very High Very High Very High
Intestinal Cancer 2 100.00 Very High Very High Very High
Cystic Kidney Diseases 8 98.72 Very High Very High Very High
INFLAMMATION 14 93.56 High High
Cyst 32 82.08 Quite High
Gastritis 1 67.44 Quite High
Polycystic Kidney Disease 62 52.96 Quite High
Cancer 33 50.00 Quite Low
Necrosis 3 50.00 Quite Low
Intestinal Polyposis 3 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Requirement of macrophages for intestinal tumour development in Apc?
Positive_regulation (Requirement) of Negative_regulation (development) of Apc in macrophages associated with intestinal cancer
1) Confidence 0.30 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.26 Pain Relevance 0.05
Overexpression of beta-catenin in transgenic animals or inactivation of APC resulted in the development of cystic kidneys [91, 92].
Positive_regulation (Overexpression) of Negative_regulation (inactivation) of APC associated with targeted disruption and cystic kidney diseases
2) Confidence 0.06 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.40 Pain Relevance 0

General Comments

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