INT235060

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.56
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Csf1) extracellular space (Csf1) extracellular region (Csf1)
plasma membrane (Csf1)
Anatomy Link Frequency
macrophages 4
Csf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 2 42.00 Quite Low
Inflammation 12 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 100.00 Very High Very High Very High
Pigmented Villonodular Synovitis 24 99.04 Very High Very High Very High
Polyps 5 93.92 High High
Intestinal Polyposis 3 89.32 High High
Carcinoma 1 85.16 High High
Severe Combined Immunodeficiency 7 77.32 Quite High
Stomach Cancer 22 77.28 Quite High
Synovial Sarcoma 1 76.24 Quite High
Clear Cell Sarcoma 1 74.80 Quite High
Myxoid Liposarcoma 1 72.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Harvested grafts maintained characteristic features of the original tumors with respect to tumor morphology, CSF1 translocation status, CSF1, and macrophage CD163 expression, making this the first PVNS model of practical use for preclinical therapeutic investigation.
Negative_regulation (maintained) of Gene_expression (expression) of CSF1 in macrophage associated with pigmented villonodular synovitis and cancer
1) Confidence 0.42 Published 2010 Journal Sarcoma Section Body Doc Link PMC2957133 Disease Relevance 1.53 Pain Relevance 0
Although it remains to be elucidated as to whether the loss of the CSF-1 function affects tumorigenesis, these results suggest that macrophages were required for the growth of Wnt/?
Spec (whether) Negative_regulation (loss) of Gene_expression (function) of CSF-1 in macrophages
2) Confidence 0.34 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 1.03 Pain Relevance 0

General Comments

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