INT235064

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.50
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Gsk3b) carbohydrate metabolic process (Gsk3b) protein complex (Gsk3b)
response to stress (Gsk3b) cytoplasm (Gsk3b) cytosol (Gsk3b)
Anatomy Link Frequency
neuronal 2
muscle 2
cerebellum 2
Gsk3b (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 21 97.36 Very High Very High Very High
cerebral cortex 4 80.36 Quite High
Eae 42 69.76 Quite High
medulla 6 64.56 Quite High
cytokine 6 61.32 Quite High
amygdala 4 55.40 Quite High
Inflammation 11 54.92 Quite High
Hippocampus 14 54.20 Quite High
long-term potentiation 10 21.60 Low Low
monoamine 12 21.32 Low Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 16 98.00 Very High Very High Very High
Alagille Syndrome 22 97.28 Very High Very High Very High
Anxiety Disorder 42 97.12 Very High Very High Very High
Cognitive Disorder 16 95.76 Very High Very High Very High
Shock 18 90.88 High High
Stomach Cancer 22 79.44 Quite High
Body Weight 7 76.80 Quite High
Cancer 32 75.12 Quite High
Targeted Disruption 71 60.80 Quite High
INFLAMMATION 14 54.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is possible that different neuronal circuits are affected by inactivation of GSK-3?
Spec (possible) Regulation (affected) of Positive_regulation (inactivation) of GSK-3 in neuronal
1) Confidence 0.41 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.46 Pain Relevance 0.09
To elucidate the involvement of the cerebellum in morphological changes in GSK-3?
Regulation (involvement) of Positive_regulation (changes) of GSK-3 in cerebellum
2) Confidence 0.36 Published 2009 Journal Mol Brain Section Body Doc Link PMC2785804 Disease Relevance 0.17 Pain Relevance 0.11
Furthermore, both glucose tolerance and insulin sensitivity showed no significant differences in 8 week (or 6 month (data not shown)) old male MLC Cre + and MLC Cre - littermate control mice (Figures 1D and 1E, respectively) demonstrating that the muscle-specific inactivation of GSK-3?
Regulation (control) of Positive_regulation (inactivation) of GSK-3 in muscle associated with tolerance and impaired glucose tolerance
3) Confidence 0.35 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.36 Pain Relevance 0.14
resulted in an increase of GSK3?
Regulation (resulted) of Positive_regulation (increase) of GSK3
4) Confidence 0.20 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.51 Pain Relevance 0.09

General Comments

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