INT235069

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 14
Disease Relevance 3.81
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdh1) cell adhesion (Cdh1) Golgi apparatus (Cdh1)
plasma membrane (Cdh1) cytoplasm (Cdh1)
Anatomy Link Frequency
intestinal epithelium 2
bladder 2
ureter 1
secretory cells 1
kidney 1
Cdh1 (Mus musculus)
Pain Link Frequency Relevance Heat
Crohn's disease 54 98.44 Very High Very High Very High
imagery 14 90.52 High High
TRP channel 10 78.52 Quite High
Inflammation 17 71.76 Quite High
addiction 6 70.64 Quite High
agonist 37 56.52 Quite High
cINOD 1 48.32 Quite Low
qutenza 25 9.28 Low Low
antagonist 55 5.28 Low Low
anesthesia 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 85 98.12 Very High Very High Very High
Targeted Disruption 71 96.88 Very High Very High Very High
Apoptosis 75 95.24 Very High Very High Very High
Stomach Cancer 22 94.04 High High
Alagille Syndrome 22 92.80 High High
Cancer 50 90.88 High High
Inflammatory Bowel Disease 12 90.60 High High
Benign Prostatic Hypertrophy 5 87.84 High High
Pathologic Processes 6 84.88 Quite High
Body Weight 18 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
E-cadherin deficiency abrogates localization and maturation of secretory cells
Localization (localization) of E-cadherin in secretory cells
1) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.05 Pain Relevance 0
As loss of E-cadherin affected localization of differentiated cells, cell migration was studied in more detail.
Localization (localization) of E-cadherin
2) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.05 Pain Relevance 0
Therefore, our study by directly targeting E-cadherin now confirms and expands these previous indirect findings and further clarifies E-cadherin's critical role as an anti-apoptotic and survival factor of the intestinal epithelium.
Localization (targeting) of E-cadherin in intestinal epithelium associated with apoptosis
3) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.30 Pain Relevance 0
These mice displayed a decrease and intracellular redistribution of E-cadherin, suggesting a role for E-cadherin in intestinal homeostasis.
Localization (redistribution) of E-cadherin
4) Confidence 0.74 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.31 Pain Relevance 0.04
Recently, polymorphisms in the CDH1 gene resulting in truncated and intracellularly mis-localized E-cadherin have been identified in patients with Crohn's disease [12].
Localization (localized) of E-cadherin associated with crohn's disease and disease
5) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.85 Pain Relevance 0.14
As the severe changes of the intestinal epithelium caused by loss of E-cadherin were not compatible with life, precluding a more detailed study of E-cadherin's role in differentiation and localization of cells, a milder recombination protocol allowing mice to survive for a longer period was developed.
Localization (localization) of E-cadherin in intestinal epithelium
6) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001873 Disease Relevance 0.07 Pain Relevance 0
Interestingly, some internalized dextran at MCJs colocalizes with internalized E-cadherin as well as ZO-1, a scaffolding protein associated with the TJs in polarized cells (Figure 3E) [70].
Localization (colocalizes) of E-cadherin
7) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0 Pain Relevance 0
As an evolutionary strategy, it is interesting that Lm targets junction remodeling and dynamin-dependent removal of E-cadherin from the cell surface as a mechanism of internalization rather than binding a more accessible, but more stable, apical receptor.
Localization (removal) of E-cadherin
8) Confidence 0.15 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2869327 Disease Relevance 0.28 Pain Relevance 0
The same authors [25] reported that such a co-localization between TRPV4 and E-cadherin was also seen in the urothelium of normal mouse bladder but not in the TRPV4 knockout mice.
Localization (localization) of E-cadherin in bladder associated with targeted disruption
9) Confidence 0.10 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.25 Pain Relevance 0.06
A co-localization between TRPV4 and E-cadherin was found throughout the urogenital tract.
Localization (localization) of E-cadherin
10) Confidence 0.10 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.24 Pain Relevance 0.10
Since TRPV4 channels are activated by mechanical stretch, Janssen et al. [24] evaluated the co-localization of these channels and adherence junctions (E-cadherin) in the urothelium of the human kidney, ureter, and bladder.
Localization (localization) of E-cadherin in ureter
11) Confidence 0.10 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.20 Pain Relevance 0.11
However, either a somatic mutation or downregulation of E-cadherin (Cheng et al, 2005), secreted frizzled-related proteins (Nojima et al, 2007), or ?
Localization (secreted) of E-cadherin
12) Confidence 0.08 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.79 Pain Relevance 0.04
Since TRPV4 channels are activated by mechanical stretch, Janssen et al. [24] evaluated the co-localization of these channels and adherence junctions (E-cadherin) in the urothelium of the human kidney, ureter, and bladder.
Localization (localization) of E-cadherin in kidney
13) Confidence 0.03 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.20 Pain Relevance 0.11
Since TRPV4 channels are activated by mechanical stretch, Janssen et al. [24] evaluated the co-localization of these channels and adherence junctions (E-cadherin) in the urothelium of the human kidney, ureter, and bladder.
Localization (localization) of E-cadherin in bladder
14) Confidence 0.03 Published 2010 Journal F1000 Biol Rep Section Body Doc Link PMC2948364 Disease Relevance 0.20 Pain Relevance 0.11

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