INT235079

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Lasting pain 5 86.48 High High
allodynia 13 81.68 Quite High
Hyperalgesia 7 71.84 Quite High
Eae 19 69.76 Quite High
Spinal cord 5 61.44 Quite High
Neuropathic pain 57 58.00 Quite High
Pain 10 25.92 Quite Low
intrathecal 3 9.84 Low Low
Etanercept 4 7.44 Low Low
Inflammation 25 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 2 93.76 High High
Pain 15 86.48 High High
Alagille Syndrome 22 82.16 Quite High
Neuropathic Pain 74 81.68 Quite High
Nervous System Injury 15 75.40 Quite High
Stomach Cancer 22 74.16 Quite High
Cold Sores 2 73.84 Quite High
Hyperalgesia 12 71.84 Quite High
Injury 23 69.76 Quite High
Frailty 2 61.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For either the stimulation or inhibition of the TNF-?
Negative_regulation (inhibition) of Phosphorylation (stimulation) of TNF
1) Confidence 0.41 Published 2008 Journal EMBO J Section Body Doc Link PMC2413189 Disease Relevance 0.28 Pain Relevance 0
Due to the unique trimeric structure shared between the TNF ligand and the TNF receptor (both belonging to the TNF/TNFR SPF), the transmembrane portion of TNF molecule (mTNF), besides being a ligand, is capable of acting as a receptor for a soluble form of TNF (sTNF) in a "reverse-signaling" manner [169], which then inhibits phosphorylation of p38 and hence expression of TNF protein.
Negative_regulation (inhibits) of Phosphorylation (phosphorylation) of TNF
2) Confidence 0.11 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.88 Pain Relevance 0.60

General Comments

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