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Context Info
Confidence 0.01
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PDE2A) signal transduction (PDE2A) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) plasma membrane (PDE2A) nucleus (PDE2A)
PDE2A (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 30 88.92 High High
5HT 13 87.60 High High
Hippocampus 27 86.68 High High
Glutamate 39 83.92 Quite High
antidepressant 1 83.60 Quite High
nMDA receptor antagonist 1 64.48 Quite High
amygdala 4 52.80 Quite High
Inflammation 2 50.00 Quite Low
depression 6 32.84 Quite Low
gABA 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 82 94.16 High High
Anxiety Disorder 22 93.72 High High
Post-traumatic Stress Disorder 88 85.76 High High
Traumatic Stress Disorders 5 50.00 Quite Low
INFLAMMATION 2 50.00 Quite Low
Neurodegenerative Disease 7 47.68 Quite Low
Dementia 1 37.56 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 37.20 Quite Low
Manic Depressive Disorder 1 36.04 Quite Low
Schizophrenia 2 34.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is in this context noteworthy that several in vitro studies have shown that activation of postsynaptic 5-HT2A/2C receptors decrease cGMP levels generated in response to NMDA administration (Marcoli et al 1997; Maura et al 2000).
Positive_regulation (generated) of Negative_regulation (decrease) of cGMP
1) Confidence 0.01 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.72 Pain Relevance 0.35

General Comments

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