INT235114

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Context Info
Confidence 0.06
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.41
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
neuronal 1
neurons 1
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 90 100.00 Very High Very High Very High
gABA 84 100.00 Very High Very High Very High
5HT 39 97.08 Very High Very High Very High
Glutamate 117 95.80 Very High Very High Very High
Hippocampus 81 89.48 High High
Central nervous system 6 71.92 Quite High
long-term potentiation 30 54.56 Quite High
ischemia 3 51.20 Quite High
Inflammation 6 50.00 Quite Low
Serotonin 9 41.44 Quite Low
Disease Link Frequency Relevance Heat
Stress 246 96.36 Very High Very High Very High
Injury 75 94.92 High High
Frailty 18 89.92 High High
Post-traumatic Stress Disorder 264 82.80 Quite High
Cognitive Disorder 27 77.20 Quite High
Neurodegenerative Disease 21 61.36 Quite High
Drug Induced Neurotoxicity 12 56.72 Quite High
Convulsion 9 52.64 Quite High
Hypoxia 3 51.84 Quite High
Cv Unclassified Under Development 3 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, high levels of corticosterone induce a rapid and non-genomic prolongation of NMDA receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons (Takahashi et al 2002), while stress-mediated changes in hippocampal spine densities are NMDA receptor dependent (Shors et al 2004).
Localization (prolongation) of NMDA receptor in neurons associated with stress and nmda receptor
1) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.96 Pain Relevance 0.41
In addition, acute release of NO via nNOS and NMDA receptor activation down-regulates the NMDA receptor, while localized release of 5HT will attenuate the mobilization of Ca2+, NO, and cGMP (Marcoli et al 1997; Maura et al 2000).
Localization (release) of NMDA receptor associated with nmda receptor and 5ht
2) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.81 Pain Relevance 0.50
Within this same context, it is pertinent to note that NO also inhibits NMDA receptor-mediated GABA release (Moller et al 1995), such that raised NO depletes neuronal GABA thus leaving the excitotoxic effects of glutamate unopposed (Figure 2).
Localization (release) of NMDA receptor in neuronal associated with glutamate, gaba and nmda receptor
3) Confidence 0.06 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.63 Pain Relevance 1.00

General Comments

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