INT235120

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.04
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.79
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN3B)
Anatomy Link Frequency
neurons 2
GRIN3B (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 60 100.00 Very High Very High Very High
5HT 26 97.52 Very High Very High Very High
Glutamate 78 95.20 Very High Very High Very High
gABA 56 91.36 High High
Hippocampus 54 90.72 High High
ischemia 2 51.20 Quite High
Inflammation 4 50.00 Quite Low
Serotonin 6 42.68 Quite Low
fluoxetine 2 35.92 Quite Low
Glutamate receptor 6 29.88 Quite Low
Disease Link Frequency Relevance Heat
Stress 164 97.40 Very High Very High Very High
Injury 50 92.12 High High
Frailty 12 91.16 High High
Post-traumatic Stress Disorder 176 84.04 Quite High
Cognitive Disorder 18 77.20 Quite High
Neurodegenerative Disease 14 61.36 Quite High
Drug Induced Neurotoxicity 8 56.72 Quite High
Convulsion 6 52.64 Quite High
Hypoxia 2 51.84 Quite High
Cv Unclassified Under Development 2 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, acute release of NO via nNOS and NMDA receptor activation down-regulates the NMDA receptor, while localized release of 5HT will attenuate the mobilization of Ca2+, NO, and cGMP (Marcoli et al 1997; Maura et al 2000).
Positive_regulation (activation) of Localization (release) of NMDA receptor associated with nmda receptor and 5ht
1) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.82 Pain Relevance 0.50
Furthermore, high levels of corticosterone induce a rapid and non-genomic prolongation of NMDA receptor-mediated Ca2+ elevation in cultured rat hippocampal neurons (Takahashi et al 2002), while stress-mediated changes in hippocampal spine densities are NMDA receptor dependent (Shors et al 2004).
Positive_regulation (induce) of Localization (prolongation) of NMDA receptor in neurons associated with stress and nmda receptor
2) Confidence 0.04 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.97 Pain Relevance 0.42

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox