INT235125

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Context Info
Confidence 0.00
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (PDE2A, Twist1) cell differentiation (Twist1) Golgi apparatus (PDE2A)
endoplasmic reticulum (PDE2A) DNA binding (Twist1) cytoplasm (PDE2A)
PDE2A (Homo sapiens)
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
antidepressant 1 89.28 High High
nMDA receptor antagonist 1 87.96 High High
Hippocampus 27 82.80 Quite High
nMDA receptor 30 78.56 Quite High
amygdala 4 76.28 Quite High
depression 6 56.32 Quite High
Inflammation 2 50.00 Quite Low
5HT 13 40.48 Quite Low
Glutamate 39 36.80 Quite Low
gABA 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 22 97.28 Very High Very High Very High
Post-traumatic Stress Disorder 88 85.12 High High
Stress 82 67.44 Quite High
Dementia 1 61.04 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 60.68 Quite High
Manic Depressive Disorder 1 59.52 Quite High
Schizophrenia 2 58.08 Quite High
Depression 6 56.32 Quite High
Traumatic Stress Disorders 5 50.00 Quite Low
INFLAMMATION 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, inhibition of cGMP breakdown by coadministration of the cGMP-selective PDE inhibitor, sildenafil, causes anxiogenic effects in the mouse elevated plus maze (Volke, Wegener, Vasar 2003; Kurt et al 2004).
cGMP Negative_regulation (inhibitor) of PDE
1) Confidence 0.00 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413191 Disease Relevance 0.99 Pain Relevance 0.24

General Comments

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