INT235130

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 2.91
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)
Anatomy Link Frequency
cleavage 2
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 3 50.52 Quite High
Pain 5 33.60 Quite Low
Calcium channel 20 29.40 Quite Low
Central nervous system 5 5.00 Very Low Very Low Very Low
midbrain 5 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Migraine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 139 100.00 Very High Very High Very High
Spinocerebellar Ataxia Type 2 51 95.36 Very High Very High Very High
Machado-joseph Disease 69 89.68 High High
Toxicity 70 87.00 High High
Ataxia 104 85.12 High High
Disease 209 60.48 Quite High
Stress 3 53.04 Quite High
Pain 5 33.60 Quite Low
Drug Induced Neurotoxicity 18 5.00 Very Low Very Low Very Low
Alzheimer's Dementia 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of all genomic elements of the ATXN3 gene allows these mice to exhibit alternative splicing of both transgenic (human) and endogenous (murine) ataxin-3.
Localization (splicing) of ATXN3 associated with targeted disruption
1) Confidence 0.75 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.68 Pain Relevance 0
In some cases, like in the case of ataxin-3 (SCA3), cleavage of the polyglutamine chain promotes aggregation (Paulson et al 1997).
Localization (case) of SCA3 in cleavage
2) Confidence 0.67 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.37 Pain Relevance 0
In some cases, like in the case of ataxin-3 (SCA3), cleavage of the polyglutamine chain promotes aggregation (Paulson et al 1997).
Localization (case) of ataxin-3 in cleavage
3) Confidence 0.67 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.37 Pain Relevance 0
Expression levels were confirmed by Western blot analysis with Flag and ataxin-3 antibodies (data not shown), and ataxin-3 subcellular localization was determined by immunofluorescence.
Localization (localization) of ataxin-3
4) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.13 Pain Relevance 0
Ub-AMC was not cleaved by buffer alone or GST-FBXO2 (Figure 3E).

2UIM ataxin-3 is more prone to aggregate than 3UIM ataxin-3

Localization (aggregate) of 2UIM ataxin-3
5) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.12 Pain Relevance 0
Ub-AMC was not cleaved by buffer alone or GST-FBXO2 (Figure 3E).

2UIM ataxin-3 is more prone to aggregate than 3UIM ataxin-3

Localization (aggregate) of 3UIM ataxin-3
6) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.13 Pain Relevance 0
The presence of all genomic elements of the ATXN3 gene allows these mice to exhibit alternative splicing of both transgenic (human) and endogenous (murine) ataxin-3.
Localization (splicing) of ataxin-3 associated with targeted disruption
7) Confidence 0.65 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.68 Pain Relevance 0
The observation that the elongated form of ataxin-3 in inclusion bodies is colocalized with the 26S proteosome complex (Chai et al 1999) implies that the proteosome could have a major role in the development of the disorder.
Localization (colocalized) of ataxin-3
8) Confidence 0.58 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.43 Pain Relevance 0.03

General Comments

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