INT235136

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.78
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Atxn1) RNA binding (Atxn1) nucleus (Atxn1)
cytoplasm (Atxn1)
Atxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 5 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 98.88 Very High Very High Very High
Ataxia 33 98.36 Very High Very High Very High
Targeted Disruption 8 96.16 Very High Very High Very High
Spinocerebellar Ataxia Type 2 17 77.16 Quite High
Retina Disease 3 5.00 Very Low Very Low Very Low
Machado-joseph Disease 3 5.00 Very Low Very Low Very Low
Cerebellar Ataxia 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although nuclear localization of ataxin-1 is necessary for the development of the disease, nuclear aggregation of ataxin-1 is not required to initiate pathogenesis in transgenic mice (Klement et al 1998).
Positive_regulation (necessary) of Localization (localization) of ataxin-1 associated with targeted disruption and disease
1) Confidence 0.38 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.78 Pain Relevance 0

General Comments

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