INT235142

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.82
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Crx) DNA binding (Crx)
Anatomy Link Frequency
photoreceptor cells 1
cortex 1
Crx (Mus musculus)
Pain Link Frequency Relevance Heat
cerebral cortex 2 84.72 Quite High
amygdala 4 80.04 Quite High
Nucleus accumbens 10 76.64 Quite High
Pyramidal cell 1 72.24 Quite High
Glutamate 1 66.80 Quite High
gABA 1 64.40 Quite High
Calcium channel 5 60.88 Quite High
Dopamine 2 56.40 Quite High
Hippocampus 9 53.36 Quite High
addiction 35 50.00 Quite Low
Disease Link Frequency Relevance Heat
Retina Disease 3 86.92 High High
Ataxia 34 85.92 High High
Targeted Disruption 20 85.12 High High
Neurological Disease 1 73.08 Quite High
Genetic Anticipation 1 65.52 Quite High
Death 2 51.48 Quite High
Apoptosis 5 51.04 Quite High
Disease 28 47.32 Quite Low
Anxiety Disorder 2 25.32 Quite Low
Spinocerebellar Ataxia Type 2 17 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In yeast 2-hybrid system, ataxin-7 interacts with CRX, a nuclear transcription factor predominantly expressed in retinal photoreceptor cells.
Gene_expression (expressed) of CRX in photoreceptor cells
1) Confidence 0.17 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.82 Pain Relevance 0.03
A final model worth mentioning involves Emx1 (empty spiracles homologue 1), a homeobox-containing gene which is specifically expressed in the developing (from E10) telencephalic cortex through adulthood [49].
Gene_expression (expressed) of homeobox-containing gene in cortex
2) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0 Pain Relevance 0.31

General Comments

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