INT235144

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Context Info
Confidence 0.44
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.79
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleocytoplasmic transport (Anp32a) endoplasmic reticulum (Anp32a) nucleus (Anp32a)
cytoplasm (Anp32a)
Anatomy Link Frequency
synapse 1
Anp32a (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 24 80.68 Quite High
Neurotransmitter 6 50.00 Quite Low
Glutamate 117 20.60 Low Low
Calcium channel 10 5.00 Very Low Very Low Very Low
chemokine 9 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
nMDA receptor 6 5.00 Very Low Very Low Very Low
Inflammation 4 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Kinase C 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 69 99.24 Very High Very High Very High
Targeted Disruption 94 95.24 Very High Very High Very High
Ataxia 66 87.20 High High
Adhesions 8 84.96 Quite High
Nervous System Malformation 8 70.40 Quite High
Spinocerebellar Ataxia Type 2 34 66.00 Quite High
Stress 26 5.00 Very Low Very Low Very Low
Death 14 5.00 Very Low Very Low Very Low
Aging 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anp32A binds to a microtubule-associated protein during neurite formation or elongation [46], Egr2 regulates myelin sheath formation during axon development [44], Ptk2b and Pitpnm2 are involved in neurite elongation and synapse formation [47], and Enc1 is involved in neuronal differentiation [45].
Anp32A Binding (binds) of in synapse
1) Confidence 0.44 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2896956 Disease Relevance 0.31 Pain Relevance 0.04
One key to understanding the mechanism of the disease caused by the mutant ataxin-1 is its interaction with LANP (leucine-rich acidic nuclear protein).
LANP Binding (interaction) of associated with disease
2) Confidence 0.11 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.74 Pain Relevance 0
One key to understanding the mechanism of the disease caused by the mutant ataxin-1 is its interaction with LANP (leucine-rich acidic nuclear protein).
leucine-rich acidic nuclear protein Binding (interaction) of associated with disease
3) Confidence 0.11 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.74 Pain Relevance 0

General Comments

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