INT235150

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Context Info
Confidence 0.32
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.48
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ppp2r2b) signal transduction (Ppp2r2b) mitochondrion (Ppp2r2b)
cytoskeleton (Ppp2r2b) cytoplasm (Ppp2r2b)
Anatomy Link Frequency
brain 2
Ppp2r2b (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 5 80.32 Quite High
Migraine 1 68.08 Quite High
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 28 87.84 High High
Ataxia 33 71.12 Quite High
Migraine With Aura 1 69.68 Quite High
Cerebellar Ataxia 3 42.12 Quite Low
Spinocerebellar Ataxia Type 2 17 38.80 Quite Low
Ocular Toxicity (including Many Sub-types) 2 26.48 Quite Low
Ophthalmoplegia 1 23.96 Low Low
Neurodegenerative Disease 2 19.76 Low Low
Tremor 1 12.68 Low Low
Dysarthria 1 11.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SCA12 is caused by a CAG repeat expansion that is not transcribed to polyglutamine and is speculated to affect the expression of the gene PPP2R2B, which encodes a brain-specific regulatory subunit of protein phosphatase PP2A (Holmes et al 1999).
Regulation (affect) of Gene_expression (expression) of PPP2R2B in brain
1) Confidence 0.32 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.48 Pain Relevance 0.11

General Comments

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