INT235152

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Context Info
Confidence 0.17
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.72
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Dnaja1) protein folding (Dnaja1)
Anatomy Link Frequency
neurons 1
Dnaja1 (Mus musculus)
Pain Link Frequency Relevance Heat
Calcium channel 5 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ataxia 33 98.80 Very High Very High Very High
Targeted Disruption 8 95.00 High High
Disease 28 83.52 Quite High
Spinocerebellar Ataxia Type 2 17 51.04 Quite High
Repression 1 6.40 Low Low
Retina Disease 3 5.00 Very Low Very Low Very Low
Machado-joseph Disease 3 5.00 Very Low Very Low Very Low
Cerebellar Ataxia 3 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cummings et al (1998) found colocalization of the 20S proteosome and chaperone HSJ2, a member of the Hsp40 family, with large nuclear inclusions of ataxin-1 in brain neurons of patients with SCA1 and in mice transgenic for a mutant SCA1 allele containing 82 glutamines.
Localization (colocalization) of HSJ2 in neurons associated with targeted disruption
1) Confidence 0.17 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.72 Pain Relevance 0

General Comments

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