INT235157

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 10
Disease Relevance 6.74
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Atxn2) nucleus (Atxn2) cytoplasm (Atxn2)
Anatomy Link Frequency
neuronal 1
brain 1
Purkinje cells 1
mesenchymal cells 1
Atxn2 (Mus musculus)
Pain Link Frequency Relevance Heat
Thalamus 16 94.28 High High
Hippocampus 96 93.88 High High
Pyramidal cell 8 91.04 High High
amygdala 168 88.08 High High
long-term potentiation 208 87.40 High High
Calcium channel 10 5.28 Low Low
Pain 24 5.00 Very Low Very Low Very Low
depression 8 5.00 Very Low Very Low Very Low
Eae 8 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Spinocerebellar Ataxia Type 2 122 100.00 Very High Very High Very High
Ataxia 74 100.00 Very High Very High Very High
Neurodegenerative Disease 20 99.60 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 24 98.88 Very High Very High Very High
Targeted Disruption 176 98.32 Very High Very High Very High
Anxiety Disorder 376 97.40 Very High Very High Very High
Cognitive Disorder 16 97.08 Very High Very High Very High
Parkinson's Disease 8 96.20 Very High Very High Very High
Disease 72 95.96 Very High Very High Very High
Congenital Anomalies 56 94.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ataxin-2 is a cytoplasmic protein that is expressed throughout the brain [5].
Gene_expression (expressed) of Ataxin-2 in brain
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.87 Pain Relevance 0
Relationship to SCA2 phenotype
Gene_expression (phenotype) of SCA2 associated with spinocerebellar ataxia type 2
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 1.06 Pain Relevance 0.10
Delineating behavioral consequences of Atxn2 deficiency in the mouse is thus important for understanding pathology in SCA2 patients and selective forces in Northern Europeans.
Gene_expression (deficiency) of Atxn2 associated with spinocerebellar ataxia type 2
3) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.85 Pain Relevance 0.25
During mouse development, ataxin-2 is expressed as early as embryonic day 8 (E8) in mesenchymal cells and the heart, with a burst of expression at E11 [5].
Gene_expression (expressed) of ataxin-2 in mesenchymal cells
4) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.44 Pain Relevance 0.18
Despite widespread expression of ataxin-2 throughout development, homozygous Atxn2 knockout mice were viable, fertile and did not display obvious anatomical or histological abnormalities [14].
Gene_expression (expression) of ataxin-2 associated with targeted disruption and congenital anomalies
5) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.82 Pain Relevance 0.16
Murine ataxin-2 is widely expressed in both neuronal and nonneuronal tissues.
Gene_expression (expressed) of ataxin-2 in neuronal
6) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.49 Pain Relevance 0.15
32 repeats cause spinocerebellar ataxia type 2, a human neurodegenerative disease.
Gene_expression (cause) of spinocerebellar ataxia type 2 associated with spinocerebellar ataxia type 2 and neurodegenerative disease
7) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.61 Pain Relevance 0.25
Generation of an Atxn2 loss-of-function allele was described previously [14].
Gene_expression (Generation) of Atxn2
8) Confidence 0.53 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2707006 Disease Relevance 0.41 Pain Relevance 0.13
The source of the mutation in many genetic subtypes of ataxias (SCA1, SCA2, SCA3, SCA6, SCA7, SCA12, and SCA17) is the same (CAG repeat expansion), and the resulting protein product contains a long polyglutamine domain.
Gene_expression (source) of SCA2 associated with ataxia
9) Confidence 0.44 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 1.11 Pain Relevance 0
Mice expressing ataxin-2 showed functional progressive deficits accompanied with the final loss of Purkinje cells resulting from aggregation in cytoplasm.
Gene_expression (expressing) of ataxin-2 in Purkinje cells
10) Confidence 0.44 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.09 Pain Relevance 0

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