INT23518

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Context Info
Confidence 0.32
First Reported 1985
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 1.11
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ctsa) nucleolus (Ctsa) nucleus (Ctsa)
molecular_function (Ctsa) cellular_component (Ctsa) biological_process (Ctsa)
Anatomy Link Frequency
chondrocytes 1
spinal cord 1
spleen 1
Ctsa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 57 99.44 Very High Very High Very High
Pain 32 98.70 Very High Very High Very High
Neuropathic pain 30 98.60 Very High Very High Very High
Enkephalin 2 96.84 Very High Very High Very High
Dorsal horn 9 83.04 Quite High
Osteoarthritis 1 78.44 Quite High
bradykinin 4 70.00 Quite High
medulla 6 58.52 Quite High
imagery 3 57.96 Quite High
Lasting pain 12 56.96 Quite High
Disease Link Frequency Relevance Heat
Arthralgia 1 98.70 Very High Very High Very High
Neuropathic Pain 51 98.60 Very High Very High Very High
Arthropathy 2 93.20 High High
Helminth Infection 64 89.28 High High
Arthritis 4 84.44 Quite High
Pain 42 83.84 Quite High
Intestinal Volvulus 13 5.00 Very Low Very Low Very Low
Injury 12 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low
INFLAMMATION 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Intra-articular pain during gonarthrosis: a case report about an extremely increased cathepsin expression in chondrocytes].
Gene_expression (expression) of cathepsin in chondrocytes associated with pain and arthralgia
1) Confidence 0.32 Published 2007 Journal Zeitschrift für Orthopädie und Unfallchirurgie Section Title Doc Link 17607629 Disease Relevance 0.36 Pain Relevance 0.22
AL and IB carried out the L5T surgeries and behavioral analysis, the immunohistochemical analysis and the activity assays; WW established the activity assays; MA helped with L5T surgeries; BS identified the cathepsin overexpression and performed preliminary experiments; CCS and HL conceived the study and oversaw all components including manuscript preparation.
Gene_expression (overexpression) of cathepsin
2) Confidence 0.28 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0 Pain Relevance 0.12
[Properties and specificity of cathepsin H from the bovine spleen].
Gene_expression ([Properties) of cathepsin H in spleen
3) Confidence 0.27 Published 1985 Journal Vopr. Med. Khim. Section Title Doc Link 2418588 Disease Relevance 0 Pain Relevance 0.22
Primary antibodies were used to document CATS and CATX and to identify the cathepsin-expressing cells.
Gene_expression (expressing) of cathepsin
4) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0 Pain Relevance 0
Differential expression of Cathepsin S and X in the spinal cord of a rat neuropathic pain model

Background

Gene_expression (expression) of Cathepsin S in spinal cord associated with neuropathic pain and spinal cord
5) Confidence 0.25 Published 2008 Journal BMC Neurosci Section Title Doc Link PMC2527007 Disease Relevance 0.41 Pain Relevance 0.60
To determine the possible function(s) of the B. malayi cathepsin-like cysteine protease genes during embryogenesis of B. malayi, RNAi was carried out to selectively interfere with Bm cathepsin-like cysteine protease gene expression; Bm-cpz or Bm-cpl.
Gene_expression (expression) of cathepsin
6) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2634747 Disease Relevance 0.35 Pain Relevance 0

General Comments

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