INT23519

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Context Info
Confidence 0.41
First Reported 1982
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 12
Disease Relevance 3.84
Pain Relevance 10.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tacr1) response to stress (Tacr1) cytoplasm (Tacr1)
signal transducer activity (Tacr1)
Anatomy Link Frequency
spinal cord 8
spinal cord dorsal horn 4
Vagal nerve 2
dorsal horn 2
spinal 2
Tacr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 87 100.00 Very High Very High Very High
Dorsal horn 22 100.00 Very High Very High Very High
Spinal cord 18 100.00 Very High Very High Very High
Calcitonin gene-related peptide 3 100.00 Very High Very High Very High
qutenza 48 99.98 Very High Very High Very High
Nerve growth factor 1 99.80 Very High Very High Very High
Inflammation 12 99.60 Very High Very High Very High
Somatostatin 5 99.60 Very High Very High Very High
Serotonin 2 99.60 Very High Very High Very High
Sciatic nerve 2 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 11 99.60 Very High Very High Very High
Nociception 7 99.36 Very High Very High Very High
Injury 7 97.16 Very High Very High Very High
Neuropathic Pain 8 96.88 Very High Very High Very High
Ganglion Cysts 1 96.84 Very High Very High Very High
Pox Virus Infection 1 93.16 High High
Hypersensitivity 1 91.12 High High
Inflammatory Pain 2 90.88 High High
Skin Diseases 1 88.88 High High
Eczema 2 88.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intradermal injection of capsaicin induces acute substance P release from rat spinal cord dorsal horn.
Positive_regulation (induces) of Localization (release) of substance P in spinal cord dorsal horn associated with qutenza, dorsal horn, spinal cord and substance p
1) Confidence 0.41 Published 2006 Journal Neurosci. Lett. Section Title Doc Link 17101224 Disease Relevance 0 Pain Relevance 1.44
Increased release of substance P (SP) from the dorsal horn following noxious stimuli, such as spinal administration of capsaicin, has been demonstrated in previous studies.
Positive_regulation (Increased) of Localization (release) of substance P in spinal associated with qutenza, dorsal horn and substance p
2) Confidence 0.41 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 17101224 Disease Relevance 0 Pain Relevance 0.84
Compound 48/80 does not activate nerve fibres to cause release of substance P as it is equally effective in eliciting an inflammatory response in the presence of 100 micrograms of the substance P antagonist D-Pro4, D-Trp7,9,10 SP(4-11) in the synovial cavity.
Positive_regulation (cause) of Localization (release) of substance P in cavity associated with inflammatory response, antagonist and substance p
3) Confidence 0.40 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2484727 Disease Relevance 0.44 Pain Relevance 1.07
Low but not high rate noxious radiant skin heating evokes a capsaicin-sensitive increase in spinal cord dorsal horn release of substance P.
Positive_regulation (increase) of Localization (release) of substance P in spinal cord dorsal horn associated with qutenza, dorsal horn, substance p and spinal cord
4) Confidence 0.39 Published 1997 Journal Brain Res. Section Title Doc Link 9106450 Disease Relevance 0.40 Pain Relevance 1.59
Numerous in vitro studies suggest that inflammation is associated with enhanced release of substance P (SP) in the dorsal horn.
Positive_regulation (enhanced) of Localization (release) of substance P in dorsal horn associated with inflammation, dorsal horn and substance p
5) Confidence 0.23 Published 2004 Journal Neurosci. Lett. Section Abstract Doc Link 15351454 Disease Relevance 0.40 Pain Relevance 0.82
In sham-operated animals, topical application of capsaicin cream to both sides of the hind paw, the instep and sole, as well as antidromic stimulation of the sciatic nerve led to a significant increase in the amounts of Evans blue and substance P (SP) released into the perfusates.
Positive_regulation (increase) of Localization (released) of substance P in paw associated with qutenza, sciatic nerve and substance p
6) Confidence 0.21 Published 2001 Journal Pain Section Abstract Doc Link 11323147 Disease Relevance 0.47 Pain Relevance 0.99
High concentrations of K+ increase the release of substance P (SP) and somatostatin (SRIF) from superfused slices of rat spinal cord.
Positive_regulation (increase) of Localization (release) of substance P in spinal cord associated with somatostatin, spinal cord and substance p
7) Confidence 0.15 Published 1982 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 6180329 Disease Relevance 0 Pain Relevance 0.64
In vitro superfusion with capsaicin (5 X 10(-7) M) of slices of the dorsal half of the rat spinal cord produced a significant increase in a release of immunoreactive substance P (iSP).
Positive_regulation (increase) of Localization (release) of substance P in spinal cord associated with qutenza, substance p and spinal cord
8) Confidence 0.10 Published 1987 Journal Brain Res. Section Abstract Doc Link 2435372 Disease Relevance 0.16 Pain Relevance 0.63
Previous studies in vitro have shown that NK3 receptors exist on primary afferent terminals in rat spinal cord and mediate potentiation of the depolarisation-evoked substance P (SP) release.
Positive_regulation (mediate) of Localization (release) of substance P in spinal cord associated with substance p and spinal cord
9) Confidence 0.10 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10665827 Disease Relevance 0.36 Pain Relevance 0.73
Vagal nerve stimulation caused a release of substance P (SP) and serotonin (5-HT) into the feline portal circulation.
Positive_regulation (caused) of Localization (release) of substance P in Vagal nerve associated with serotonin and substance p
10) Confidence 0.09 Published 1985 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2418634 Disease Relevance 0 Pain Relevance 0.26
Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones.
Positive_regulation (induced) of Localization (release) of substance P in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, nerve growth factor, qutenza and substance p
11) Confidence 0.09 Published 2010 Journal Clin. Exp. Dermatol. Section Title Doc Link 19874332 Disease Relevance 0.63 Pain Relevance 0.52
In vitro, BCTC inhibited capsaicin (300 nM)-induced releases of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) from the rat spinal cord slice preparations with IC(50)s of 37.0 and 36.0 nM, respectively, confirming that BCTC potently inhibits TRPV1 function in the rat spinal cord.
Positive_regulation (induced) of Localization (releases) of substance P-like immunoreactivity in spinal cord associated with qutenza, spinal cord, substance p and calcitonin gene-related peptide
12) Confidence 0.09 Published 2005 Journal Neuropharmacology Section Abstract Doc Link 15998524 Disease Relevance 0.97 Pain Relevance 1.28

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