INT235196

Context Info Confidence 0.62 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 5 Total Number 5 Disease Relevance 2.68 Pain Relevance 0.17

cytosol (VIM) plasma membrane (VIM) cytoskeleton (VIM) cytoplasm (VIM)

Anatomy Link Frequency cleavage 1 apoptotic cells 1 VIM (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 2 64.16 Chronic pancreatitis 30 56.92 Immobilon 9 11.96 cytokine 32 5.00 Inflammation 14 5.00 corticosteroid 2 5.00 ischemia 2 5.00 cINOD 1 5.00 dexamethasone 1 5.00 addiction 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 19 99.76 Autolysis 5 98.96 Cancer 145 98.80 Pancreatic Cancer 144 97.52 Hepatocellular Cancer 3 91.28 Autoimmune Disease 16 85.84 Stress 4 78.20 Ductal Carcinoma 3 72.92 Pain 2 64.16 Reprotox - General 1 3 63.60

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We hypothesized that perhaps specific protease cleavage of intact vimentin resulted in the observed antigenicity.

Protein_catabolism (cleavage) of vimentin in cleavage

1) Confidence 0.62 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 0.27 Pain Relevance 0.11

Prasad et al. (25) have reported apoptosis-associated proteolysis of vimentin in human prostate epithelial tumor cells and demonstrated that vimentin undergoes limited proteolysis in the apoptotic cells.

Protein_catabolism (proteolysis) of vimentin in apoptotic cells associated with cancer and apoptosis

2) Confidence 0.62 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.06 Pain Relevance 0

Importantly, in vitro studies have demonstrated that vimentin is subject to caspase-mediated proteolysis in an apoptosis-related manner (24).

Protein_catabolism (proteolysis) of vimentin associated with apoptosis

3) Confidence 0.62 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2528299 Disease Relevance 1.11 Pain Relevance 0

Our results suggested that vimentin was increased by LPS priming (spots O and S at 48–50 kDa on the gels), and that in the absence of LPS, vimentin was cleaved into smaller fragments (spot E at 24 kDa on the gels) (Table 1 and Additional File 5).

Protein_catabolism (cleaved) of vimentin

4) Confidence 0.23 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0.08 Pain Relevance 0

While autolysis causes down-regulation of p94 as a whole molecule, proteolysis of vimentin would confer other properties on certain parts of the molecule.

Protein_catabolism (proteolysis) of vimentin associated with autolysis

5) Confidence 0.15 Published 2007 Journal Biotechnology Journal Section Body Doc Link PMC2978325 Disease Relevance 0.16 Pain Relevance 0.06

General Comments

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