INT235200

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.68
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (ELANE) extracellular region (ELANE) cytoplasm (ELANE)
Anatomy Link Frequency
leukocyte 2
ELANE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 77 95.04 Very High Very High Very High
metalloproteinase 20 68.08 Quite High
Arthritis 5 67.60 Quite High
cytokine 32 66.96 Quite High
Inflammatory response 7 26.96 Quite Low
Prostatitis 21 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alveolar Bone Loss 1 100.00 Very High Very High Very High
Periodontal Disease 48 98.16 Very High Very High Very High
INFLAMMATION 88 95.04 Very High Very High Very High
Diabetes Mellitus 22 85.76 High High
Infection 40 80.32 Quite High
Disease 24 68.96 Quite High
Arthritis 6 67.60 Quite High
Cardiovascular Disease 12 56.00 Quite High
Stress 31 50.00 Quite Low
Metabolic Disorder 7 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A significant positive Spearman’s correlation (p=0.000001) was found between increased leukocyte count (>10 per hpf) and elevated PMN elastase level in EPS (r= 0.66).
Positive_regulation (elevated) of Negative_regulation (level) of elastase in leukocyte
1) Confidence 0.38 Published 2008 Journal Arch Immunol Ther Exp (Warsz) Section Body Doc Link PMC2778713 Disease Relevance 0.47 Pain Relevance 0.12
If elastase inhibitor is responsible for blocking priming for enhanced release of superoxide, the endogenous protease that might be involved in regulating priming could be either a serine protease or a cysteine protease.
Positive_regulation (responsible) of Negative_regulation (inhibitor) of elastase
2) Confidence 0.15 Published 2008 Journal Proteome Sci Section Body Doc Link PMC2413206 Disease Relevance 0 Pain Relevance 0.06
In a rat model of induced periodontal disease using gingival LPS injections, elevated levels of collagenase (MMP-8), gelatinase (MMP-9), elastase and alveolar bone loss were overcome by using a synergistic combination of sub-optimal doses of the chemically modified tetracycline CMT-8 and a biphosphonate, clodronate [86]; when sub-optimal doses of these agents were used individually, there were negligible effects on the above parameters.
Positive_regulation (overcome) of Negative_regulation (loss) of elastase associated with alveolar bone loss and periodontal disease
3) Confidence 0.00 Published 2008 Journal The Open Dentistry Journal Section Body Doc Link PMC2581528 Disease Relevance 1.21 Pain Relevance 0.28

General Comments

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