INT23524

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Context Info
Confidence 0.57
First Reported 1986
Last Reported 2009
Negated 2
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.25
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
vertebrae 1
VCF (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 17 99.78 Very High Very High Very High
cva 134 97.64 Very High Very High Very High
Angina 2 87.76 High High
Pain management 1 76.80 Quite High
backache 2 72.96 Quite High
Spinal cord 3 69.92 Quite High
depression 1 68.44 Quite High
Pain refractory 1 28.56 Quite Low
Analgesic 3 27.04 Quite Low
anesthesia 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Compression Fractures 55 100.00 Very High Very High Very High
Osteoporosis 8 99.80 Very High Very High Very High
Pain 15 99.78 Very High Very High Very High
Deep Vein Thrombosis 119 99.32 Very High Very High Very High
Pulmonary Embolism 58 97.64 Very High Very High Very High
Kyphosis 6 94.08 High High
Coronary Artery Disease 3 90.04 High High
Stable Angina Pectoris 1 87.76 High High
Cv General 3 Under Development 5 86.64 High High
Injury 112 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
If the stiffness of vertebral bodies infiltrated with PMMA is in fact the cause of an increased risk of subsequent VCF, the use of bone as graft material may be useful in adjacent vertebrae fracture risk reduction.
Positive_regulation (increased) of VCF in vertebrae
1) Confidence 0.57 Published 2007 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2684215 Disease Relevance 0.30 Pain Relevance 0.10
The primary goal of vertebroplasty is pain relief by stabilization of the continuously sintering VCF [8].
Positive_regulation (stabilization) of VCF associated with compression fractures and pain
2) Confidence 0.44 Published 2008 Journal Patient Saf Surg Section Body Doc Link PMC2248169 Disease Relevance 1.41 Pain Relevance 0.39
No increased rate of secondary VCF after VTP was observed in this retrospective analysis.
Neg (No) Positive_regulation (increased) of VCF
3) Confidence 0.41 Published 2008 Journal Cardiovasc Intervent Radiol Section Abstract Doc Link 18592307 Disease Relevance 0.48 Pain Relevance 0.15
Molsidomine was associated with a significant reduction of the left ventricular end-diastolic pressure and an increase in Vcf.
Positive_regulation (increase) of Vcf
4) Confidence 0.40 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154698 Disease Relevance 0.34 Pain Relevance 0.17
We assumed that the length of stay would not be increased for patients with a VCF who developed a DVT, given that they are at lower risk of PE, an assumption favourable to the prophylactic VCF strategy.


Neg (not) Positive_regulation (increased) of VCF associated with cva and deep vein thrombosis
5) Confidence 0.37 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2695771 Disease Relevance 1.71 Pain Relevance 0.34
Depressed pump function was dramatically improved with injection of 3 mg of OPC-8212, the dP/dt was elevated by 98%, the AoF by 46%, and the mean Vcf by 78%.
Positive_regulation (elevated) of Vcf
6) Confidence 0.14 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2419676 Disease Relevance 0 Pain Relevance 0
In the conscious state the same doses induced the same type of changes in hemodynamics and dimensions, but the amplitude of the response was significantly less; increase in the mean Vcf was by 36% and that of dP/dt by 52%.
Positive_regulation (increase) of Vcf
7) Confidence 0.14 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2419676 Disease Relevance 0 Pain Relevance 0

General Comments

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