INT235267

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.95
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Aldh1a1) cytoplasm (Aldh1a1)
Anatomy Link Frequency
CPA 8
Aldh1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 12 5.00 Very Low Very Low Very Low
ketamine 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 192 100.00 Very High Very High Very High
Residual Neoplasm 60 99.84 Very High Very High Very High
Cancer 1020 99.40 Very High Very High Very High
Disease 48 88.28 High High
Lung Cancer 6 85.44 High High
Solid Tumor 36 56.56 Quite High
Genetic Translocation 6 52.68 Quite High
Acute Promyelocytic Leukemia 6 50.88 Quite High
Death 18 23.88 Low Low
Hematologic Neoplasms 6 23.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UM-C6 tumors were chosen because of their high ALDH1A1 expression and relatively low expression of other ALDH family members (e.g.
Positive_regulation (high) of Gene_expression (expression) of ALDH1A1 associated with cancer
1) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.52 Pain Relevance 0
Seeing that ESA+CD44+ tumor cells have high ALDH activity, the frequency of ESA+CD44+ALDH+ cells is increased in tumors from mice treated with CPA, and ALDH1A1 gene expression is elevated in CPA-resistant CoCSC, we therefore sought to determine whether resistance to CPA was mediated by ALDH1 enzyme activity.
Positive_regulation (elevated) of Gene_expression (expression) of ALDH1A1 in CPA associated with cancer
2) Confidence 0.67 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.83 Pain Relevance 0
These observations are supported by qRT-PCR using TG or NTG cells isolated by FACS, which show that ALDH1A1 is the predominant cytoplasmic ALDH enzyme in colorectal tumors and its expression is further increased in residual tumor cells following therapy with CPA; consistent with the phenotypic increase in ALDH+ cells among the CoCSC phenotype.
Positive_regulation (increased) of Gene_expression (expression) of ALDH1A1 in CPA associated with colorectal cancer and residual neoplasm
3) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.83 Pain Relevance 0
Consistent with the hypothesis that ALDH1 may have a role in mediating resistance to CPA, ALDH1A1 gene expression was further elevated in residual cells with the CoCSC phenotype, but ALDH3A1 and ALDH5A1 were not (Figures 4B & S3).
Positive_regulation (elevated) of Gene_expression (expression) of ALDH1A1 in CPA
4) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.57 Pain Relevance 0
Since ALDH1A1 gene expression is elevated in TG versus NTG cells, ALDH1 enzymatic activity is disproportionably high in cells with the CoCSC phenotype, and this activity may mediate resistance to CPA, we next asked whether the frequency of ESA+CD44+ALDH+ cells was elevated in UM-C4, UM-C6 and OMP-C8 tumors from mice receiving CPA versus those being administered vehicle.
Positive_regulation (elevated) of Gene_expression (expression) of ALDH1A1 in CPA associated with cancer
5) Confidence 0.49 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.37 Pain Relevance 0
ALDH1A1 gene expression is 2.8-fold higher in CoCSC than in NTG cells, and despite slight elevation of ALDH3A1 expression in CoCSC versus NTG populations (Figure 3C), its message is barely detectible in either tumor line.
Positive_regulation (higher) of Gene_expression (expression) of ALDH1A1 associated with cancer
6) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.83 Pain Relevance 0

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