INT23527

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Context Info
Confidence 0.39
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 2.58
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
pituitary 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
Somatostatin 8 99.96 Very High Very High Very High
tetrodotoxin 3 99.84 Very High Very High Very High
Immobilon 2 99.66 Very High Very High Very High
substance P 4 98.88 Very High Very High Very High
Catecholamine 2 98.84 Very High Very High Very High
sodium channel 2 97.20 Very High Very High Very High
gABA 1 90.72 High High
Calcitonin gene-related peptide 1 90.24 High High
Dopamine 2 87.00 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 143 98.36 Very High Very High Very High
Blister 3 97.84 Very High Very High Very High
Metabolic Disorder 1 97.28 Very High Very High Very High
Insulin Resistance 15 91.08 High High
Apoptosis 22 10.80 Low Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Ganglion Cysts 3 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both amphetamine and fipexide inhibited in vitro the release of ME-IR.
Negative_regulation (inhibited) of Localization (release) of ME-IR
1) Confidence 0.39 Published 1986 Journal Brain Res. Section Abstract Doc Link 2879607 Disease Relevance 0 Pain Relevance 0.20
Continuous release of IR-SP was approximately 100 pg/h from the innervated footpad but was considerably reduced when the footpad had been surgically denervated 10-14 days previously.
Negative_regulation (reduced) of Localization (release) of IR-SP
2) Confidence 0.35 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2419806 Disease Relevance 0.29 Pain Relevance 0.12
Somatostatin (SRIF) inhibited both basal and K+-evoked release of ME-IR at 10(-7) M.
Negative_regulation (inhibited) of Localization (release) of ME-IR associated with somatostatin
3) Confidence 0.30 Published 1984 Journal Peptides Section Abstract Doc Link 6209687 Disease Relevance 0 Pain Relevance 0.68
Bombesin-stimulated G-IR secretion was strongly reduced by tetrodotoxin, whereas atropine had no effect.
Negative_regulation (reduced) of Localization (secretion) of G-IR associated with tetrodotoxin
4) Confidence 0.28 Published 2000 Journal Endocrinology Section Abstract Doc Link 10875263 Disease Relevance 0 Pain Relevance 0.23
In fetal cerebrocortical cells, potassium (30 and 56 mM) decreased protein synthesis and RNA levels and increased IR-SRIF release.
Negative_regulation (decreased) of Localization (release) of IR-SRIF
5) Confidence 0.24 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.36
The present results suggest that the increase of hypothalamic dopaminergic activity, in part, is related to the suppressed secretions of pituitary IR-beta-end and Prl in water deprivation, and plasma IR-beta-end play some roles in feeding behavior in rats.
Negative_regulation (suppressed) of Localization (secretions) of IR-beta-end in pituitary
6) Confidence 0.08 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 2944140 Disease Relevance 0 Pain Relevance 0.18
The addition of 0.1 microM etorphine for 3 days also decreased the basal release of MERF-IR without depleting stores of catecholamines.
Negative_regulation (decreased) of Localization (release) of MERF-IR associated with catecholamine and immobilon
7) Confidence 0.04 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3419535 Disease Relevance 0 Pain Relevance 0.41
In these cells, the basal release of Met5-enkephalin-Arg6-Phe7 immunoreactivity (MERF-IR) into the medium was significantly decreased when the cultures were pretreated with 0.2 microM reserpine for 3 days.
Negative_regulation (decreased) of Localization (release) of MERF-IR associated with enkephalin
8) Confidence 0.04 Published 1988 Journal Neuropharmacology Section Abstract Doc Link 3419535 Disease Relevance 0 Pain Relevance 0.32
Later, their glucose and Homa-IR significantly decreased and beta-cell secretion was improved.
Negative_regulation (decreased) of Localization (secretion) of Homa-IR
9) Confidence 0.03 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876602 Disease Relevance 1.32 Pain Relevance 0
GK rats are hyperglycaemic and have an impaired insulin secretion.
Negative_regulation (impaired) of Localization (secretion) of insulin
10) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2799220 Disease Relevance 0.97 Pain Relevance 0

General Comments

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