INT235271

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 1.56
Pain Relevance 0.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Aldh5a1) oxidoreductase activity (Aldh5a1)
Anatomy Link Frequency
embryo 1
CPA 1
brain 1
Aldh5a1 (Mus musculus)
Pain Link Frequency Relevance Heat
gABA 255 99.82 Very High Very High Very High
imagery 15 89.52 High High
GABAergic 15 81.84 Quite High
Neurotransmitter 20 50.00 Quite Low
Glutamate 25 47.28 Quite Low
Central nervous system 5 29.28 Quite Low
antagonist 10 5.00 Very Low Very Low Very Low
palliative 5 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 340 98.84 Very High Very High Very High
Congenital Anomalies 30 90.08 High High
Convulsion 45 80.64 Quite High
Lung Cancer 2 75.68 Quite High
Stress 5 74.08 Quite High
Colorectal Cancer 64 57.92 Quite High
Residual Neoplasm 20 5.00 Very Low Very Low Very Low
Disease 16 5.00 Very Low Very Low Very Low
Solid Tumor 12 5.00 Very Low Very Low Very Low
Adenocarcinoma 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GABA-related guanidinobutyrate (GB) reached significant increases in Aldh5a1-/- mice at ~E18–19 (Fig. 2).
Positive_regulation (increases) of Aldh5a1 associated with gaba
1) Confidence 0.55 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.09 Pain Relevance 0.18
Guanidinobutyrate (GB), also believed to derive from GABA, showed a significant increase in Aldh5a1-/- mice, but only later in gestation and at birth (Fig. 2).
Positive_regulation (increase) of Aldh5a1 associated with gaba
2) Confidence 0.55 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0 Pain Relevance 0.12
Previous studies from our laboratory demonstrated a small, yet significant, increase in total brain SSA levels for Aldh5a1-/- mice [24]; conversely, we saw no evidence for accumulation of SSA in developing embryos.
Positive_regulation (increase) of Aldh5a1 in brain
3) Confidence 0.46 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0 Pain Relevance 0
These data imply that GABA is also increased in the SSADH-deficient human fetus, consistent with our results in the murine embryo studies.


Positive_regulation (increased) of SSADH in embryo associated with gaba
4) Confidence 0.46 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.06 Pain Relevance 0.22
When considered in conjunction with the 10-fold higher proficiency of ALDH1 versus ALDH3 and SSDH at inactivating CPA intermediates [24], one might interpret these results to suggest that CoCSC resistance to CPA might be predominantly mediated by ALDH1 enzymatic activity.


Positive_regulation (proficiency) of SSDH in CPA
5) Confidence 0.45 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.44 Pain Relevance 0
Additionally, whereas ALDH5A1 is slightly elevated in TG versus NTG cells from UM-C4 tumors (?
Positive_regulation (elevated) of ALDH5A1 associated with cancer
6) Confidence 0.42 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.74 Pain Relevance 0
Our laboratory has previously shown that alterations of myelin formation occur in Aldh5a1-/- mice [28].
Positive_regulation (occur) of Aldh5a1
7) Confidence 0.40 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2642797 Disease Relevance 0.23 Pain Relevance 0.22

General Comments

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