INT235272

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Context Info
Confidence 0.12
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.35
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpa1) extracellular space (Cpa1) extracellular region (Cpa1)
Anatomy Link Frequency
CPA 4
Cpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 15 95.04 Very High Very High Very High
Potency 3 63.88 Quite High
cva 7 59.44 Quite High
Inflammation 9 50.72 Quite High
alcohol 2 49.36 Quite Low
antagonist 15 38.08 Quite Low
fibrosis 9 5.00 Very Low Very Low Very Low
Neuropathic pain 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Colorectal Cancer 32 92.68 High High
Cancer 194 89.24 High High
Metastasis 13 68.16 Quite High
Hemorrhage 6 59.44 Quite High
Aplasia 4 58.80 Quite High
Thrombocytopenia 6 58.44 Quite High
Residual Neoplasm 10 55.76 Quite High
Hematological Disease 9 54.80 Quite High
INFLAMMATION 12 50.72 Quite High
Toxicity 3 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CoCSC resistance to chemotherapy is not specific to CPA
CPA Binding (specific) of in CPA
1) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.93 Pain Relevance 0
In mammalian cells, CPA is generated intracellularly by PLD2 and acts as a second messenger which inhibits PPAR?
CPA Binding (messenger) of in CPA
2) Confidence 0.03 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.14 Pain Relevance 0.12
One of the possible explanations of this phenomenon is that on day 9 pt CPA induced activation of NADPH oxidase, which in the presence of calcium elevated superoxide production and increased cellular NO breakdown rates in these cells with a subsequent formation PN, which is involved inthe pathogenesis of conditions associated with CPA treatment [41, 42].
CPA Binding (associated) of in CPA
3) Confidence 0.02 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.05 Pain Relevance 0.03
Thus, a CPA-induced prolonged cytopenia is accompanied with a time-dependent complex nitrergic response and suggests a complex regulatory network involved inthe pathogenesis of conditions associated with CPA treatment and should be taking into account considering this in the design of chemoimmunotherapysequencing.



CPA Binding (accompanied) of in CPA
4) Confidence 0.02 Published 2008 Journal The Open Biochemistry Journal Section Body Doc Link PMC2570548 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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