INT235306

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Context Info
Confidence 0.38
First Reported 2008
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.18
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGKC)
Anatomy Link Frequency
tears 2
CPA 1
IGKC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 31 97.74 Very High Very High Very High
Inflammation 14 78.72 Quite High
cytokine 20 71.48 Quite High
cva 90 62.84 Quite High
Sicca syndrome 4 25.84 Quite Low
Kinase C 15 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Bioavailability 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Corneal Disease 240 99.84 Very High Very High Very High
Graves' Ophthalmopathy 4 93.72 High High
Apoptosis 6 85.20 High High
Leptospirosis 92 79.68 Quite High
Cancer 186 79.44 Quite High
Solid Tumor 6 79.20 Quite High
INFLAMMATION 26 78.72 Quite High
Weight Loss 4 78.32 Quite High
Obesity 6 76.52 Quite High
Colorectal Cancer 32 65.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By comparing the global protein expression in tears, we found three spots whose expression was greater in the healthy subjects (IGKC protein, ZAG, and lactoferrin) and one spot was found to be more expressed in KC patients (ZAG).
Gene_expression (expressed) of IGKC protein in tears associated with corneal disease
1) Confidence 0.38 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 0.63 Pain Relevance 0
Founded differences in ZAG, lactoferrin, and IGKC expression were subsequently validated by western blot.


Gene_expression (expression) of IGKC
2) Confidence 0.38 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2965569 Disease Relevance 0.37 Pain Relevance 0
Finally, we found a significant decrease in protein expression for IGKC in KC patients.
Gene_expression (expression) of IGKC associated with corneal disease
3) Confidence 0.33 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965569 Disease Relevance 1.03 Pain Relevance 0.13
IGKC protein, ZAG, and lactoferrin are under-expressed in the tears of patients diagnosed with bilateral KC compared with healthy subjects.
Gene_expression (expressed) of IGKC protein in tears associated with corneal disease
4) Confidence 0.33 Published 2010 Journal Molecular Vision Section Abstract Doc Link PMC2965569 Disease Relevance 0.37 Pain Relevance 0
7-fold lower (apparent Km values of 54 ± 6.0 and 7.6 ± 1.4 ?
Gene_expression (values) of Km
5) Confidence 0.15 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2801295 Disease Relevance 0 Pain Relevance 0
ALDH1, in particular, may play a major role in CPA resistance, as it's Km for CPA is ?
Gene_expression (is) of Km in CPA
6) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2413402 Disease Relevance 0.52 Pain Relevance 0
Although, so far, there is no complete data available for enzyme kinetic parameters of the serum PAF-AH towards this artificial substrate, its Km was determined in this study, which is similar to that of the L-PAF-AH.
Spec (determined) Gene_expression (determined) of Km
7) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.19 Pain Relevance 0.03
Meanwhile, the Km of the human serum PAF-AH towards the artificial substrate was found to be 0.27 mM assayed by the same methodology (Table 1), which is in the same order of magnitude with that of the rL-PAF-AH (0.61 mM).


Gene_expression (found) of Km
8) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2615213 Disease Relevance 0.06 Pain Relevance 0
As illustrated in Fig 2A, CPE coexpression significantly increased the maximal uptake velocity (Vmax) of [3H] DA by ~50% (DAT: Vmax = 10.8 ± 1 pmol/min/well; DAT+CPE: 16 ± 1.9 pmol/min/well; P < 0.01), whereas no significant change in the estimated Km of the DAT could be observed (DAT: Km = 6.6 ± 0.7 ?
Neg (no) Gene_expression (change) of Km associated with dopamine
9) Confidence 0.05 Published 2009 Journal Mol Brain Section Body Doc Link PMC2687442 Disease Relevance 0 Pain Relevance 0.17

General Comments

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