INT235325

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.20
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ntrk2) endosome (Ntrk2) aging (Ntrk2)
plasma membrane (Ntrk2)
Anatomy Link Frequency
myocardium 2
neurons 2
Ntrk2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 5 89.76 High High
cytokine 16 87.04 High High
Potency 2 74.08 Quite High
Inflammation 6 64.16 Quite High
Spinal cord 1 11.36 Low Low
Pain 1 8.48 Low Low
agonist 7 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 1 70.20 Quite High
INFLAMMATION 6 64.16 Quite High
Myocardial Infarction 7 61.40 Quite High
Coronary Artery Disease 7 44.48 Quite Low
Ventricular Remodeling 1 29.60 Quite Low
Arrhythmogenic Right Ventricular Dysplasia 1 17.80 Low Low
Calcification 1 16.24 Low Low
Cicatrix 3 15.52 Low Low
Cancer 5 15.28 Low Low
Pain 1 8.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many of the NMDA protective actions are attributed to BDNF secretion, which then activates TrkB receptors on this neuron itself or on surrounding neurons to elicit survival responses.
Positive_regulation (attributed) of Localization (secretion) of TrkB in neurons
1) Confidence 0.23 Published 2010 Journal Cell Mol Life Sci Section Body Doc Link PMC2858808 Disease Relevance 0 Pain Relevance 0.04
Second, bone marrow cells may play a different role in the environment of ischemic myocardium or acute infarcted myocardium, and it is possible that stronger angiogenesis is induced by the implantation of bone marrow cells in ischemic myocardium, where they survive longer and are stimulated to secrete more angiogenic factors such as VEGF.
Positive_regulation (stimulated) of Localization (secrete) of factors in myocardium
2) Confidence 0.01 Published 2008 Journal J Cardiothorac Surg Section Body Doc Link PMC2414821 Disease Relevance 0.20 Pain Relevance 0.14

General Comments

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