INT23533

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Context Info
Confidence 0.75
First Reported 1986
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 110
Total Number 122
Disease Relevance 30.81
Pain Relevance 19.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
reticulum 5
neurons 4
epithelial cells 3
keratinocytes 2
neutrophils 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 186 100.00 Very High Very High Very High
Morphine 262 99.84 Very High Very High Very High
Prostatitis 748 99.76 Very High Very High Very High
antagonist 275 99.76 Very High Very High Very High
Calcium channel 76 99.68 Very High Very High Very High
qutenza 198 99.56 Very High Very High Very High
agonist 502 99.54 Very High Very High Very High
Kinase C 40 99.52 Very High Very High Very High
alcohol 201 99.40 Very High Very High Very High
dorsal root ganglion 167 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 156 100.00 Very High Very High Very High
Volume Depletion And Dehydration 124 100.00 Very High Very High Very High
Stress 507 99.90 Very High Very High Very High
Cancer 373 99.86 Very High Very High Very High
Osteopetrosis 72 99.84 Very High Very High Very High
Prostatitis 748 99.76 Very High Very High Very High
Benign Prostatic Hypertrophy 35 99.60 Very High Very High Very High
Hyperplasia 24 99.60 Very High Very High Very High
Pancreatic Cancer 6 99.58 Very High Very High Very High
Disease 681 99.46 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As control cases, we also investigated expression of EMA and carbonic anhydrase II in an ocular globe with retinal gliosis and three cases of myxopapillary ependymoma of the cauda equina.
Spec (investigated) Gene_expression (expression) of carbonic anhydrase II in globe associated with ependymoma and gliosis
1) Confidence 0.75 Published 2005 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16160486 Disease Relevance 0.97 Pain Relevance 0.10
Pathologic features and particularly expression of carbonic anhydrase II suggest a derivation from intrinsic glial cells of retina otherwise known as Muller cells.
Gene_expression (expression) of carbonic anhydrase II in glial cells
2) Confidence 0.75 Published 2005 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16160486 Disease Relevance 0.71 Pain Relevance 0.03
The hippocampal CA2 region is thought to be especially vulnerable to this ?
Gene_expression (region) of CA2
3) Confidence 0.65 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2965495 Disease Relevance 0.80 Pain Relevance 0
Tumor cells expressed GFAP and S-100 and to lesser extent carbonic anhydrase II.
Gene_expression (expressed) of carbonic anhydrase II associated with cancer
4) Confidence 0.65 Published 2005 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 16160486 Disease Relevance 0.86 Pain Relevance 0.13
Sustained exposure of the neurons to abused drugs significantly increased the KCl (30 mM)-induced 45Ca2+ influx and enhanced expression of alpha1 subunits for L-type high voltage-gated Ca2+ channels (HVCCs).
Gene_expression (expression) of Ca2 in neurons
5) Confidence 0.58 Published 2004 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 15542765 Disease Relevance 0.73 Pain Relevance 0.73
The purpose of this investigation was to determine in a neuronal cell which source of Ca2+ underlying the carbachol-evoked transient increase in cytoplasmic Ca2+ was reduced by isoflurane.
Gene_expression (source) of Ca2 in neuronal associated with isoflurane
6) Confidence 0.52 Published 2003 Journal Anesthesiology Section Abstract Doc Link 14508321 Disease Relevance 0 Pain Relevance 0.30
The source of Ca2+ responsible for contraction was examined in suspensions of smooth muscle cells and in perfused single muscle cells from guinea pig and human stomach.
Spec (examined) Gene_expression (source) of Ca2 in smooth muscle cells
7) Confidence 0.52 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 2420205 Disease Relevance 0 Pain Relevance 0.07
This pattern is consistent with an earlier report in which serum inorganic phosphorus levels were found to be higher during the menstrual phase than in the other two phases.[11] The decrease in inorganic phosphorus levels with increased follicular Ca2+/Mg2+ ratios in the luteal phase as compared to the menstrual phase could be due to estrogen as reported earlier.[21] The present study also compares well with an earlier observation that high estrogen production can lead to a decrease in serum inorganic phosphorus levels.[24]

CONCLUSION

Gene_expression (ratios) of Ca2
8) Confidence 0.50 Published 2008 Journal Journal of Human Reproductive Sciences Section Body Doc Link PMC2700668 Disease Relevance 0.54 Pain Relevance 0.40
The source, time course and stoichiometry of cytosolic free Ca2+ ([Ca2+]i) during contraction were examined in smooth muscle cells isolated from the guinea pig and human stomach.
Spec (examined) Gene_expression (source) of Ca2 in stomach
9) Confidence 0.50 Published 1988 Journal Mol. Cell. Biochem. Section Abstract Doc Link 3263564 Disease Relevance 0 Pain Relevance 0.24
After Ca2+-containing medium is introduced, a sustained increase in cytosolic Ca2+ is observed for both treatments (Figure 6A, 6B).
Gene_expression (introduced) of Ca2
10) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Taken together, this model predicts that in HEK293 cells, the level of cytosolic Ca2+ associated with Echinacea treatment increases through two mechanisms: initially the release of Ca2+ from ER Ca2+ stores, and subsequently Ca2+ influx via SOCE.
Gene_expression (stores) of Ca2
11) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.14 Pain Relevance 0.04
Calcium stored in the ER is released through Ca2+ channels in the ER membrane, usually via the IP3 receptor or ryanodine receptor families [15].
Gene_expression (channels) of Ca2
12) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.06 Pain Relevance 0.16
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Gene_expression (sources) of Ca2 in reticulum
13) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Ca2+ pumps located in the ER membranes then return cytosolic Ca2+ into the lumen, thus contributing to Ca2+ homeostasis between the cytoplasm and ER.
Gene_expression (return) of Ca2 in lumen
14) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.07 Pain Relevance 0.16
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Gene_expression (stores) of Ca2 in reticulum
15) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Two principal sources of Ca2+ affect the concentration of cytosolic Ca2+: internal Ca2+ stores, primarily in the endoplasmic reticulum (ER), and extracellular Ca2+.
Gene_expression (stores) of Ca2 in reticulum
16) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Ca2+ pumps located in the ER membranes then return cytosolic Ca2+ into the lumen, thus contributing to Ca2+ homeostasis between the cytoplasm and ER.
Gene_expression (return) of Ca2 in lumen
17) Confidence 0.42 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.07 Pain Relevance 0.16
The expression of CFTR and CAII is up-regulated in human prostatitis
Gene_expression (expression) of CAII associated with prostatitis
18) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.37 Pain Relevance 0.15
We also examined the effect of E.coli-LPS on CFTR and CAII expression in cultured prostate epithelial cells.
Gene_expression (expression) of CAII in epithelial cells
19) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.54 Pain Relevance 0.36
We thus examined CFTR and CAII expression in human prostate hyperplasia samples with inflammation.
Spec (examined) Gene_expression (expression) of CAII associated with benign prostatic hypertrophy and inflammation
20) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2998414 Disease Relevance 0.58 Pain Relevance 0.21

General Comments

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