INT23535

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 13.52
Pain Relevance 9.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
internal 10
reticulum 6
MCF-7 4
skeletal muscle 2
muscle cells 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 158 99.98 Very High Very High Very High
nMDA receptor 33 99.98 Very High Very High Very High
Morphine 234 99.92 Very High Very High Very High
qutenza 11 98.84 Very High Very High Very High
Glutamate 144 98.44 Very High Very High Very High
anesthesia 17 98.42 Very High Very High Very High
Opioid 302 97.44 Very High Very High Very High
Enkephalin 162 96.24 Very High Very High Very High
Inflammation 227 94.72 High High
Calcium channel 27 94.72 High High
Disease Link Frequency Relevance Heat
Infection 23 100.00 Very High Very High Very High
Apoptosis 63 99.20 Very High Very High Very High
Muscle Disease 1 95.76 Very High Very High Very High
Malignant Hyperthermia 5 95.60 Very High Very High Very High
Hepatocellular Cancer 3 95.56 Very High Very High Very High
INFLAMMATION 237 94.72 High High
Pain 162 92.72 High High
Post-traumatic Stress Disorder 88 92.04 High High
Sepsis 52 91.56 High High
Prostate Cancer 3 91.04 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Isoflurane reduction of the carbachol-evoked transient increase in cytoplasmic Ca2+ requires full caffeine-sensitive Ca2+ stores and Ca2+ release from the caffeine-sensitive stores through the ryanodine-sensitive Ca2+ release channels.
Positive_regulation (requires) of Localization (release) of Ca2
1) Confidence 0.41 Published 2003 Journal Anesthesiology Section Body Doc Link 14508321 Disease Relevance 0 Pain Relevance 0
CONCLUSIONS: Isoflurane reduction of the carbachol-evoked transient increase in cytoplasmic Ca2+ requires full caffeine-sensitive Ca2+ stores and Ca2+ release from the caffeine-sensitive stores through the ryanodine-sensitive Ca2+ release channels.
Positive_regulation (requires) of Localization (release) of Ca2
2) Confidence 0.41 Published 2003 Journal Anesthesiology Section Body Doc Link 14508321 Disease Relevance 0 Pain Relevance 0
The results indicate that contractile agonists cause release of Ca2+ from a depletable intracellular store in gastric muscle cells.
Positive_regulation (cause) of Localization (release) of Ca2 in muscle cells associated with agonist
3) Confidence 0.40 Published 1986 Journal Am. J. Physiol. Section Abstract Doc Link 2420205 Disease Relevance 0 Pain Relevance 0.21
During general anesthesia, a life-threatening hypermetabolic state may occur resulting from increased release of Ca2+ from the sarcoplasmic reticulum in skeletal muscle.
Positive_regulation (increased) of Localization (release) of Ca2 in skeletal muscle associated with anesthesia
4) Confidence 0.40 Published 2002 Journal Anesthesiology Section Abstract Doc Link 12411787 Disease Relevance 0.62 Pain Relevance 0.10
Collectively, these results suggest that the capsaicin-induced apoptosis in the HepG2 cells may result from the activation of a PLC-dependent intracellular Ca2+ release pathway, and it is further suggested that capsaicin may be valuable for the therapeutic intervention of human hepatomas.
Positive_regulation (activation) of Localization (release) of Ca2 associated with qutenza, hepatocellular cancer and apoptosis
5) Confidence 0.39 Published 2005 Journal Arch. Pharm. Res. Section Abstract Doc Link 15742812 Disease Relevance 0.86 Pain Relevance 0.86
Ghrelin induced Ca2+ transients in one third of the myenteric neurons, involving release of Ca2+ from intracellular stores and direct GHS-receptor activation.
Positive_regulation (induced) of Localization (release) of Ca2 in neurons
6) Confidence 0.38 Published 2008 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 18630723 Disease Relevance 0 Pain Relevance 0.11
The adrenergic agonist-induced increases in [Ca2+]i were due to both release of Ca2+ from intracellular stores and entry of extracellular Ca2+.
Positive_regulation (due) of Localization (release) of Ca2 associated with agonist
7) Confidence 0.32 Published 1995 Journal Biochem. Pharmacol. Section Abstract Doc Link 7530955 Disease Relevance 0.23 Pain Relevance 0.25
In the absence of extracellular Ca2+, both agents evoke a transient intracellular Ca2+ elevation, interpreted as being due to Ca2+ release from internal stores.
Positive_regulation (due) of Localization (elevation) of Ca2 in internal
8) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
In the absence of extracellular Ca2+, both agents evoke a transient intracellular Ca2+ elevation, interpreted as being due to Ca2+ release from internal stores.
Positive_regulation (due) of Localization (release) of Ca2 in internal
9) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.03
Based on studies with a range of inhibitors, activators and experimental conditions, we propose that Echinacea extract contains compounds other than its known alkamides that induce cytosolic Ca2+ release, in combination with an ER-depletion-associated activation of the SOCE pathway in HEK293 cells.


Positive_regulation (induce) of Localization (release) of Ca2
10) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.17
This model predicts that the Echinacea-induced release of Ca2 from internal stores may be coupled to a subsequent activation of the SOCE process.
Positive_regulation (activation) of Localization (release) of Ca2 in internal
11) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.20 Pain Relevance 0.11
Thapsigargin and 2-ABP inhibition experiments indicate that Echinacea extract may induce Ca2+ influx by activating SOCE following depletion of Ca2+ from intracellular stores
Positive_regulation (activating) of Localization (depletion) of Ca2
12) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0 Pain Relevance 0.08
In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].
Positive_regulation (causing) of Localization (release) of Ca2
13) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.08 Pain Relevance 0.08
In this metabotropic model, PLC activation would lead to the production of IP3, which in turn would activate the IP3 receptor causing release of Ca2+ from the ER [15].
Positive_regulation (activate) of Localization (release) of Ca2
14) Confidence 0.31 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.09 Pain Relevance 0.09
Other Direct Mechanisms
  Caffeine also inhibits inositol triphosphate (IP3) compound which stimulates the secretion of Ca2+ from the sarcoplasmic reticulum and is indispensable for contraction.  
Positive_regulation (stimulates) of Localization (secretion) of Ca2 in reticulum
15) Confidence 0.30 Published 2010 Journal International Journal of Vascular Medicine Section Body Doc Link PMC3003984 Disease Relevance 0 Pain Relevance 0
The elevations in [Ca2+]i can lead to further release of Ca2+ from the endoplasmic reticulum, and the activation of the caspase-dependent apoptosis pathway through changes in mitochondrial membrane permeability (Rizzuto et al., 2003).
Positive_regulation (lead) of Localization (release) of Ca2 in reticulum associated with apoptosis
16) Confidence 0.29 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2874397 Disease Relevance 0.30 Pain Relevance 0.06
Taken together, this model predicts that in HEK293 cells, the level of cytosolic Ca2+ associated with Echinacea treatment increases through two mechanisms: initially the release of Ca2+ from ER Ca2+ stores, and subsequently Ca2+ influx via SOCE.
Positive_regulation (increases) of Localization (release) of Ca2
17) Confidence 0.29 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3002894 Disease Relevance 0.15 Pain Relevance 0.04
, we examined their effects on U46619-induced [Ca2+]i mobilization, Rho activation, F-actin polymerization and cofilin phosphorylation by TP?
Positive_regulation (activation) of Localization (mobilization) of Ca2
18) Confidence 0.27 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
On the other hand, pre-stimulation with Cicaprost impaired U46619-induced [Ca2+]i mobilization and RhoA activation by TP?
Positive_regulation (activation) of Localization (mobilization) of Ca2
19) Confidence 0.27 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.09
Consistent with those previous studies, pre-incubation with SIN-1 specifically impaired U46619-induced [Ca2+]i mobilization in HEK.TP?
Positive_regulation (incubation) of Localization (mobilization) of Ca2
20) Confidence 0.27 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.03

General Comments

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