INT23536

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Context Info
Confidence 0.09
First Reported 1985
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.51
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 3
heart 1
Bp43 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 7 92.60 High High
antagonist 4 88.32 High High
potassium channel 1 75.00 Quite High
cva 2 36.64 Quite Low
Disease Link Frequency Relevance Heat
Death 1 98.48 Very High Very High Very High
Hypotension 2 93.68 High High
Shock 3 88.44 High High
Endotoxemia 1 75.00 Quite High
Stroke 1 66.40 Quite High
Hemorrhage 2 36.64 Quite Low
Toxicity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mean blood pressure (MBP) decreased from 121 +/- 5.7 mmHg to 79 +/- 5.6 at 5 and 15 min, and increased to 113 +/- 3.0 at 180 min.
Negative_regulation (decreased) of Mean blood pressure in blood
1) Confidence 0.09 Published 1985 Journal Circ. Shock Section Abstract Doc Link 4092342 Disease Relevance 0.31 Pain Relevance 0.26
An intravenous injection of 1 mg/kg captopril significantly decreased mean blood pressure (MBP) and raised PRA.
Negative_regulation (decreased) of mean blood pressure in blood
2) Confidence 0.04 Published 1985 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2420298 Disease Relevance 0.09 Pain Relevance 0
Administration of the local anaesthetic bupivacaine (1.5 or 2 mg/kg, i.v.) to rats elicited a marked decrease of mean arterial blood pressure (MBP) and heart rate (HR) leading to death (in 67% or 90% of animals respectively).
Negative_regulation (decrease) of arterial blood pressure in heart associated with death
3) Confidence 0.02 Published 1989 Journal Pharmacol. Res. Section Abstract Doc Link 2594614 Disease Relevance 0.10 Pain Relevance 0.08
In pentobarbital-anesthetized dogs, YM934 (1-10 micrograms/kg intravenously, i.v.) dose-dependently increased coronary artery blood flow (CBF), and decreased total peripheral resistance (TPR) and mean blood pressure (MBP).
Negative_regulation (decreased) of mean blood pressure in blood
4) Confidence 0.01 Published 1994 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 7511745 Disease Relevance 0 Pain Relevance 0.08

General Comments

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